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MetabolomicsPhosphoethanolamine Cytidylyltransferase 2 Integrates DAG Metabolism and TBK1 Activation to Regulate Antiviral Innate Immunity

Phosphatidylethanolamine (PE) biosynthesis is critical for membrane biology and cellular homeostasis. However, its specific role in antiviral innate immunity remains poorly understood. Here, we demonstrate that inhibition of phosphoethanolamine cytidylyltransferase 2 (PCYT2), a key enzyme in...

2026-05-07 | MTBLS14085 | MetaboLights
TranscriptomicsIn vitro responses of fibroblasts from patients with TBK1 deficiency after TLR3 dependent and independent stimuli
We report here two unrelated HSE patients carrying different heterozygous mutations (D50A and G159A) in TBK1, the gene encoding TANK-binding kinase 1, a kinase at the crossroads of multiple IFN-inducing signaling pathways. Both mutant TBK1 alleles are loss-of-function, but through different mechanis...
ORGANISM(S): Homo sapiens 
2012-07-29 | E-GEOD-38652 | biostudies-arrayexpress
ProteomicsAnalysis of the TBK1 interactors from TBK1-deficient A549 cells reconstituted with moTAP TBK1 or empty vector
This study aimed at determining the proteins that interact with TBK1.
ORGANISM(S): Homo sapiens (Human) 
2018-09-25 | PXD010777 | Pride
A549 Tbk1 
TranscriptomicsTranscription profiling of mouse wild-type, TBK1, IKKi(Ikbke), or TBK1 IKKi doubly deficient embryonic fibroblats to elucidate how TBK1 and/or IKKi mediates B-DNA-mediated innate immune responses
B-DNA-induced gene expression profile in wild-type, TBK1, IKKi(Ikbke), or TBK1 IKKi doubly deficient embryonic fibroblats; to elucidate how TBK1 and/or IKKi mediates B-DNA-mediated innate immune responses. Experiment Overall Design: Total RNA was extracted from embryonic fibroblats transfected for 4...
ORGANISM(S): Mus musculus 
2007-12-07 | E-GEOD-4171 | biostudies-arrayexpress
ProteomicsTBK1-mediated LC3C phosphorylation site identification
In order to identify TBK1-mediated LC3C phosphorylation sites, proteins were overexpressed in SILAC labelled cells.
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015076 | Pride
Lc3c Tbk1 
ProteomicsTBK1-mediated GABARAP-L2 phosphorylation site identification
In order to identify TBK1-mediated GABARAP-L2 phosphorylation sites, proteins were overexpressed in SILAC labelled cells.
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015075 | Pride
Tbk1 Gabarapl2 
ProteomicsNAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
Supporting raw MS data for paper (DOI:10.1083/jcb.202303082) by Paul S. et al., titled "NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis". Index of MS supporting files uploaded: - Related to Figure 6A;S4A (AO3556-AO3579: whole proteome (Unimod: 35; 2016; 4)). -...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-01 | MSV000093220 | MassIVE
Proteomicsendogenous TBK1-mediated GABARAP-L2 and LC3C phosphorylation site identification
In order to identify TBK1-mediated GABARAP-L2 and LC3C phosphorylation sites, cells were treated with TBK1 or control siRNA and TBK1 kinase activity was induced by treatment with CCCP.
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015077 | Pride
Lc3c Tbk1 Gabarap-l2 
ProteomicsTBK1-mediated phosphorylation sites of ATG8s in vitro
Identification of LC3 family proteins phoshorylation sites mediated by TBK1
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015065 | Pride
Lc3c Tbk1 Gabarap-l2 
ProteomicsPhospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks
Identification of TBK1 interactors in control iNeurons with AP-MS
ORGANISM(S): Homo sapiens (Human) 
2025-09-19 | PXD068535 | Pride
Ap-ms Tbk1 Ineurons 
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