Sort   by:  
 Page size 
ProteomicsUSP14 inhibition enhances Parkin-independent mitophagy in iNeurons
Loss of proteostasis is well documented during physiological aging and depends on the progressive decline in the activity of two major degradative mechanisms: the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway. This decline in proteostasis is exacerbated in age-associated neur...
ORGANISM(S): Homo sapiens (Human) 
2024-12-18 | PXD056511 | Pride
Usp14 Mitophagy Autophagy Ups Parkin March5/mitol Pink1 
ProteomicsEndo-IP and Lyso-IP Toolkit for Endolysosomal Profiling of Human Induced Neurons
We developed a toolkit for capturing endosomes (Endo-IP) and lysosomes (Lyso-IP) in human stem cell(hESC)-derived induced neurons (iNeurons). We target a sub-population of early endosomes marked by endogenously tagged EEA1 (Early Endosome Antigen 1) protein, which represents one of the earliest popu...
ORGANISM(S): Homo sapiens (Human) 
2025-01-11 | PXD055978 | Pride
Human Tmt Endosomes Ineurons Lysosomes 
UnknownUSP14 inhibition enhances Parkin-independent mitophagy in iNeurons.
Not available
S-EPMC12849831 | biostudies-literature
UnknownGlobal Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling.
Not available
S-EPMC7098486 | biostudies-literature
ProteomicsPhospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks
Identification of TBK1 interactors in control iNeurons with AP-MS
ORGANISM(S): Homo sapiens (Human) 
2025-09-19 | PXD068535 | Pride
Ap-ms Tbk1 Ineurons 
UnknownC9orf72-ALS mutation drives basal mitophagy impairments in iNeurons.
Not available
S-EPMC12933941 | biostudies-literature
GenomicsThe deletion of the Williams-Beuren Syndrome critical region dysregulate the expression of miR379-410 miRNA members in human isogenic iNeurons
The deletion of the Williams-Beuren Syndrome critical region dysregulate the expression of miR379-410 miRNA members in human isogenic iNeurons
PRJNA1040287 | ENA
ProteomicsQuaNCAT analysis comparing proteins synthesized in neurites and soma in ASCL1-iNeurons
Local translation in ASCL1-iNeurons was probed using QuaNCAT
ORGANISM(S): Mus musculus (Mouse) 
2018-10-17 | PXD005059 | Pride
Azidohomoalanine Mouse Silac 
TranscriptomicsSingle-cell RNA sequencing of Ngn2-induced neurons from the pluripotent stem cells of great apes
We generated induced excitatory sensory neurons (iNeurons, iNs) from pluripotent stem cells of great apes (Human, Chimpanzee and Bonobo) by expressing the transcription factor neurogenin 2 (Ngn2). Single cell-RNA sequencing was performed to identify gene expressions differing in dendrite and synapse...
ORGANISM(S): Pan paniscus 
2020-12-15 | E-MTAB-9233 | biostudies-arrayexpress
UnknownA HaloTag-4R-Tau Pulse-Chase Sensor Reveals Neddylation Inhibition Promotes Degradation of Tau in iNeurons.
Not available
S-EPMC12874043 | biostudies-literature
Sort   by:  
 Page size