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ProteomicsGABARAP-L2 WT, S87/88D or A interactomes
TBK1 phosphorylates GABARAP-L2 S87/88. In order to test if this phosphomimetic mutation in GABARAP-L2 changes its binding to other proteins a mass spectrometry based interactome study was performed.
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015155 | Pride
Gabarap-l2 
Proteomicsendogenous TBK1-mediated GABARAP-L2 and LC3C phosphorylation site identification
In order to identify TBK1-mediated GABARAP-L2 and LC3C phosphorylation sites, cells were treated with TBK1 or control siRNA and TBK1 kinase activity was induced by treatment with CCCP.
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015077 | Pride
Lc3c Tbk1 Gabarap-l2 
ProteomicsTBK1-mediated GABARAP-L2 phosphorylation site identification
In order to identify TBK1-mediated GABARAP-L2 phosphorylation sites, proteins were overexpressed in SILAC labelled cells.
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015075 | Pride
Tbk1 Gabarapl2 
UnknownTBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease.
Not available
S-EPMC6945063 | biostudies-literature
ProteomicsTumor immune evasion through IRGQ-directed autophagy
The autophagy-lysosome system directs the degradation of a wide variety of cargo and is also involved in tumor progression. Here we show that immunity-related GTPase family Q protein (IRGQ) acts in the quality control of MHC-I molecules and directs misfolded MHC-I for lysosomal degradation through i...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-28 | PXD044618 | Pride
Lc3b Autophagy Immune evasion Hepatocellular carcinoma Irgq Gabarap-l2 Mhc class i 
ProteomicsGABARAPL2 WT, S10D or A interactomes
TBK1 phosphorylates GABARAPL2 S10. In order to test if this phosphomimetic mutation in GABARAPL2 changes its binding to other proteins a mass spectrometry based interactome study was performed.
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD066665 | Pride
Gabarapl2 Autophagy Tbk1 Interactome 
ProteomicsHDX-MS analysis of IRGQ in the presence of GABARAP-L2 and LC3B
The autophagy-lysosome system directs the degradation of a wide variety of cargo and is also involved in tumor progression. Here we show that immunity-related GTPase family Q protein (IRGQ) acts in the quality control of MHC-I molecules and directs misfolded MHC-I for lysosomal degradation through i...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-11-26 | PXD045212 | Pride
Hdx-ms Irgq Ligand binding 
UnknownSystematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux.
Not available
S-EPMC5730722 | biostudies-literature
UnknownPlasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation.
Not available
S-EPMC11582615 | biostudies-literature
ProteomicsTBK1-mediated phosphorylation sites of ATG8s in vitro
Identification of LC3 family proteins phoshorylation sites mediated by TBK1
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD015065 | Pride
Lc3c Tbk1 Gabarap-l2 
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