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ProteomicsHDX-MS analysis of IRGQ in the presence of GABARAP-L2 and LC3B
The autophagy-lysosome system directs the degradation of a wide variety of cargo and is also involved in tumor progression. Here we show that immunity-related GTPase family Q protein (IRGQ) acts in the quality control of MHC-I molecules and directs misfolded MHC-I for lysosomal degradation through i...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-11-26 | PXD045212 | Pride
Hdx-ms Irgq Ligand binding 
ProteomicsIRGQ-GABARAPL2 complex interactome
GABARAPL2 is the only hATG8 able to fit in the LIR1-G1 loop pocket of IRGQ. To further dissect this striking evolutionary specificity, we queried the interactome of the IRGQ-GABARAPL2 complex with proteomics by using the Venus complementation affinity purification (BiCAP) method.
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD066671 | Pride
Irgq Autophagy Gabarapl2 
ProteomicsTumor immune evasion through IRGQ-directed autophagy
interactome of endogenous IRGQ during basal and autophagy-inducing conditions
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD045117 | Pride
Human 
ProteomicsTumor immune evasion through IRGQ-directed autophagy
The autophagy-lysosome system directs the degradation of a wide variety of cargo and is also involved in tumor progression. Here we show that immunity-related GTPase family Q protein (IRGQ) acts in the quality control of MHC-I molecules and directs misfolded MHC-I for lysosomal degradation through i...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-28 | PXD044618 | Pride
Lc3b Autophagy Immune evasion Hepatocellular carcinoma Irgq Gabarap-l2 Mhc class i 
ProteomicsTumor immune evasion mediated through IRGQ-directed autophagy
SurfaceOME of IRGQ WT and KO 8988T cells under basal conditions
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD045259 | Pride
Human 
ProteomicsTotal porteome of liver tumors from mice (p53, MYC driven)
The autophagy-lysosome system directs the degradation of a wide variety of cargo and is also involved in tumor progression. Here we show that immunity-related GTPase family Q protein (IRGQ) acts in the quality control of MHC-I molecules and directs misfolded MHC-I for lysosomal degradation through i...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-31 | PXD044985 | Pride
Tmt Liver Myc Mice P53 
UnknownHPV E6/E7-Induced Acetylation of a Peptide Encoded by a Long Non-Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer.
Not available
S-EPMC11905060 | biostudies-literature
TranscriptomicsERK activation, gene dysregulations and cell transformation at submicromolar doses of Cr6+ in C3H10T1/2 and BALB/c 3T3 cells: interaction with Lipoic acid
The molecular mechanism of Cr6+ carcinogenicity is not well understood. Studies advocate a key involvement of the altered cytogenomics and dysregulated pathways in Cr6+ toxicity. However, the dissimilarity in expression of genes and pathways in cells transformed by Cr6+ has led us to supplement more...
ORGANISM(S): Mus musculus 
2015-12-31 | GSE43156 | GEO
TranscriptomicsERK activation, gene dysregulations and cell transformation at submicromolar doses of Cr6+ in C3H10T1/2 and BALB/c 3T3 cells: interaction with Lipoic acid
The molecular mechanism of Cr6+ carcinogenicity is not well understood. Studies advocate a key involvement of the altered cytogenomics and dysregulated pathways in Cr6+ toxicity. However, the dissimilarity in expression of genes and pathways in cells transformed by Cr6+ has led us to supplement more...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-43156 | biostudies-arrayexpress
ProteomicsGABARAPL2 WT, S10D or A interactomes
TBK1 phosphorylates GABARAPL2 S10. In order to test if this phosphomimetic mutation in GABARAPL2 changes its binding to other proteins a mass spectrometry based interactome study was performed.
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD066665 | Pride
Gabarapl2 Autophagy Tbk1 Interactome 
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