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TranscriptomicsMicroarray profiling of pluripotent stem cell derived cardiomyocytes pretreated with DMSO, DHS (10µM final concentration) and co-incubation of DHS and curcumin (10µM final concentrations) for 3 consecutive days.
hCMs pretreated with DMSO : DMSO-1 and DMSO-2 hCMs pretreated with DHS: Sph1, Sph2 and Sph3 hCMs pretreated with DHS+ Curcumin: Sph+Cur1, Sph+Cur2 and Sph+Cur3
ORGANISM(S): Homo sapiens 
2019-03-22 | E-MTAB-7530 | biostudies-arrayexpress
ProteomicsInteraction of human eIF5A and DHS K329A variant studied by HDX-MS
Hypusination is a unique post-translational modification of the eukaryotic translation factor 5A (eIF5A) that is essential for overcoming ribosome stalling at polyproline sequence stretches. The initial step of hypusination, the formation of deoxyhypusine, is catalyzed by deoxyhypusine synthase (DHS...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-05-10 | PXD040460 | Pride
Eif5a Hdx-ms Synapt-g2 si Dhs k329a variant 
GenomicsLentzea guizhouensis strain:DHS C013
Lentzea guizhouensis strain:DHS C013 Genome sequencing and assembly
PRJNA328305 | ENA
ProteomicsEvaluation of N8-propargyl spermidine and spermine as substrates of deoxyhypusine synthase in the in vitro hypusination of eIF5A and RIPK1
eIF5A is a well-established protein substrate of deoxyhypusine synthase (DHS), which also requires spermidine as a small-molecule substrate. At the end of 2024, a publication claimed that RIPK1 is an additional DHS substrate and that N8-propargyl spermidine can also serve as a DHS substrate. To eval...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD071577 | Pride
N8-propargyl spermidine Dhs Eif5a Chemical probe Hypusination Deoxyhypusine synthase Ripk1 
GenomicsEpigenetic landscape of olfactory receptor enhancers
Distant enhancer elements are a major source of specificity in mammalian gene expression. Although enhancers that regulate broad developmental decisions and inducible gene expression have been studied extensively, little is known about regulatory elements that govern monogenic and monoallelic expres...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-55174 | biostudies-arrayexpress
GenomicsDHS NS5 Cells
DHS NS5 Cells
PRJEB5275 | ENA
GenomicsGenome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation (Dnase-Seq)
DHS enahncers to identify novel pathways in OB differentiation We examined DHS identified enhancers and promoters during OB differentiation
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-75231 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation (microarray)
DHS enahncers identify novel pathways in OB differentiation We examined gene expression and compared to DHS on promoters and enhancers during OB differentiation
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-75230 | biostudies-arrayexpress
GenomicsThe B cell identity factor Pax5 regulates distinct transcriptional programs in early and late B lymphopoiesis
Pax5 controls the identity and development of B cells by repressing lineage-inappropriate genes and activating B-cell-specific genes. Here, we used genome-wide approaches to identify Pax5 target genes in pro-B and mature B cells. In these cell types, Pax5 bound to 40% of the cis- regulatory elements...
ORGANISM(S): Mus musculus 
2012-06-14 | E-GEOD-38046 | biostudies-arrayexpress
GenomicsDHS study in grass
We reported genome-wide DNase I-hypersensitive site (DHS) maps from diverse tissues (leaf, stem, and root) in the three grasses
PRJEB32944 | ENA
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