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TranscriptomicsRole of the pseudokinase Tribbles homologue 3 in cancer
samples obtained in triplicates from RasV12/E1A-transformed embryoninc fibroblasts derived from Trib3+/+ and Trib3-/- mice.
ORGANISM(S): Mus musculus 
2014-09-18 | E-MEXP-3979 | biostudies-arrayexpress
ProteomicsEvolutionary and cellular analysis of the'dark'pseudokinase PSKH2
Pseudokinases, so named because they lack one or more conserved canonical amino acids that define their catalytically-active relatives, have evolved a variety of biological functions in both prokaryotic and eukaryotic organisms. Human PSKH2 is closely related to the canonical kinase PSKH1, which map...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD039306 | Pride
Pseudokinase Pskh2 
ProteomicsStructural insightsStructural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3 into regulation of the PEAK3 pseudokinase scaffold by 14-3-3
The three members of the PEAK family of pseudokinases (PEAK1, PEAK2, and PEAK3) are molecular scaffolds that have recently emerged as important nodes in signaling pathways that control cell migration, morphology, and proliferation, and are increasingly found mis-regulated in human cancers. While no...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD035574 | Pride
Human Ap-ms Lc-msms Peak3 
UnknownThe pseudokinase domain in receptor guanylyl cyclases.
Not available
S-EPMC7612907 | biostudies-literature
ProteomicsHuman RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3. To mediate necroptosis, RIPK3 must stably interact with, and phosphorylate the pseudokinase domain of MLKL. While ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-30 | PXD033488 | Pride
Tnf Programmed necrosis Pseudokinase Protein kinase Ripk1 
UnknownReceptor tyrosine kinases with intracellular pseudokinase domains.
Not available
S-EPMC3777422 | biostudies-literature
UnknownComputational tools and resources for pseudokinase research.
Not available
S-EPMC9733567 | biostudies-literature
UnknownMolecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.
Not available
S-EPMC4508010 | biostudies-literature
UnknownIdentification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.
Not available
S-EPMC5467198 | biostudies-literature
Genomics
Overexpression of Plasmodiophora brassicae pseudokinase in Arabidopsis
PRJNA1458947 | ENA
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