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ProteomicsLC–MS/MS Proteomic Profiling of PEAK3 S69 Phosphorylation in PEAK3 Mutants
This project aims to investigate how different PEAK3 mutations affect phosphorylation at serine 69 (S69). To this end, we performed proteomic analyses on immunoprecipitated (IP) PEAK3 samples from both wild-type and mutant constructs. Peptides containing phosphorylated and non-phosphorylated S69 wer...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD071947 | Pride
Proteomics Peak3 Breast cancer Lc-ms/ms 
ProteomicsCharacterization of PEAK3 pseudokinase as a pro-migratory and -invasive member of New Kinase Family 3
The New Kinase Family 3 (NKF3) of pseudokinases comprises PEAK1 and PEAK2 as well as the recently-identified PEAK3. PEAK1/2 play fundamental roles in regulating tyrosine kinase signal output and oncogenesis, while PEAK3 remains poorly-characterized. Here we demonstrate that PEAK3 undergoes homotypic...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD023687 | Pride
Nkf3/ peak1 (sgk269)/ peak2 (sgk223 Pragmin)/ peak3/brest cancer 
ProteomicsInteractomic analysis of PEAK3 pseudo-kinase
The aim of the project was to identify the interactome of PEAK3 pseudokinase that was expressed in various cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2022-01-04 | PXD029417 | Pride
Adhesive protein Pseudo-kinase Oncogene Signalling protein 
ProteomicsStructural insightsStructural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3 into regulation of the PEAK3 pseudokinase scaffold by 14-3-3
The three members of the PEAK family of pseudokinases (PEAK1, PEAK2, and PEAK3) are molecular scaffolds that have recently emerged as important nodes in signaling pathways that control cell migration, morphology, and proliferation, and are increasingly found mis-regulated in human cancers. While no...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD035574 | Pride
Human Ap-ms Lc-msms Peak3 
UnknownStructural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
Not available
S-EPMC10279700 | biostudies-literature
UnknownPEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.
Not available
S-EPMC6681764 | biostudies-literature
UnknownStructural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.
Not available
S-EPMC10279719 | biostudies-literature
UnknownSerum N-Glycans: A New Diagnostic Biomarker for Light Chain Multiple Myeloma.
Not available
S-EPMC4468189 | biostudies-literature
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