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ProteomicsHDX-MS of NicA2 and a NicA2 variant with increased activity
Here we have used HDX-MS to investigate the change in structure/dynamics in NicA2 and a variant with increased activity (v321) that was generated using directed evolution
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD037151 | Pride
Nica2 Directed evolution Nicotine oxidoreductase 
UnknownThe nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats.
Not available
S-EPMC6056991 | biostudies-literature
UnknownDirected evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme.
Not available
S-EPMC10611581 | biostudies-literature
UnknownBinding Interface and Electron Transfer Between Nicotine Oxidoreductase and Its Cytochrome c Electron Acceptor.
Not available
S-EPMC10163435 | biostudies-literature
UnknownAn enzymatic advance in nicotine cessation therapy.
Not available
S-EPMC6231713 | biostudies-literature
UnknownA cytochrome c is the natural electron acceptor for nicotine oxidoreductase.
Not available
S-EPMC7904663 | biostudies-literature
UnknownMolecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022).
Not available
S-EPMC7468206 | biostudies-literature
UnknownCrystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.
Not available
S-EPMC6295333 | biostudies-literature
UnknownThe enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase.
Not available
S-EPMC9396064 | biostudies-literature
UnknownRational design of a flavoenzyme for aerobic nicotine catabolism.
Not available
S-EPMC11481913 | biostudies-literature
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