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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownA three marker signature to distinguish Small cell from large cell neuroendocrine carcinoma: Study at transcriptomic and protein level
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-44447 | biostudies-other
UnknownBACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4<sup>+</sup> T cells.
Not available
S-EPMC12490260 | biostudies-literature
TranscriptomicsA three marker signature to distinguish Small cell from large cell neuroendocrine carcinoma: Study at transcriptomic and protein level
To identify potential markers for distinction of Small cell (SCLC) from large cell neuroendocrine (LCNEC) carcinoma, we have conducted the gene expression profiling on precisely isolated cancer cells and bronchial epithelial cells from these tumours and normal background lung. After statistical anal...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-44447 | biostudies-arrayexpress
UnknownNeuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation.
Not available
S-EPMC7146643 | biostudies-literature
UnknownAberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.
Not available
S-EPMC6542723 | biostudies-literature
TranscriptomicsExpression data from fibroblasts cultured from normal and fibrotic human lung tissue
Pulmonary fibrosis develops as a consequence of environmentally induced lung injury and/or an inherent disease susceptibility causing fibroblast activation, proliferation and extracellular matrix deposition. The study was undertaken to characterise global gene expression in pulmonary fibroblasts to ...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-40839 | biostudies-arrayexpress
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-30405 | biostudies-arrayexpress
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