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TranscriptomicsNicotinamide mononucleotide, a key NAD+ precursor, treats the pathophysiology of diet- and age-induced diabetes
Type 2 diabetes (T2D) has become an epidemic in our modern lifestyle, likely due to calorie-rich diets overwhelming our adaptive metabolic pathways. One such pathway is mediated by nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD+ biosynthesis, and the NAD+-...
ORGANISM(S): Mus musculus 
2011-12-05 | E-GEOD-31647 | biostudies-arrayexpress
ProteomicsReduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Suppresses Glycolysis and Cell Growth
In the present study, we developed a chemical method to produce dihydro nicotinamide mononucleotide (NMNH), which is the reduced-form of nicotinamide mononucleotide (NMN). We demonstrated that NMNH was a better nicotinamide adenine dinucleotide (NAD+) enhancer compared to NMN both in vitro and in vi...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD022547 | Pride
Nicotinamide adenine dinucleotide (nad+ and nadh) Reduced nicotinamide mononucleotide (nmnh) Cell growth Nicotinamide mononucleotide adenylyltransferase (nmnat) Tca cycle Glycolysis 
ProteomicsNicotinamide Mononucleotide modifies Clinical and IgE Responses in an Ovalbumin-induced murine model of Allergy and Anaphylaxis
Allergic reactions and anaphylactic shock are severe systemic immune responses that can cause extensive tissue injury and disruption of organ architecture. Although the pathophysiology of allergy and anaphylaxis involves profound inflammatory responses, the mechanisms underlying tissue injury and th...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-15 | PXD082609 | Pride
Nicotinamide mononucleotide anaphylaxis  immune modulation 
GenomicsSlc12a8 is a nicotinamide mononucleotide transporter that counteracts aging
Slc12a8 is a nicotinamide mononucleotide transporter that counteracts aging
PRJNA485337 | ENA
GenomicsNicotinamide mononucleotide increases muscle insulin sensitivity in women with prediabetes
Nicotinamide mononucleotide increases muscle insulin sensitivity in women with prediabetes
PRJNA663592 | ENA
GenomicsEffect of nicotinamide mononucleotide on doxorubicin-induced cardiac injury in mice
Effect of nicotinamide mononucleotide on doxorubicin-induced cardiac injury in mice
PRJNA977218 | ENA
Proteomicsβ-Nicotinamide mononucleotide restores mitochondrial function and muscle strength in septic male mice
Sepsis remains a leading cause of mortality and long-term disability, with survivors frequently developing intensive care unit–acquired weakness (ICU-AW) as part of post-intensive care syndrome. To identify a nutritional therapy for ICU-AW, we investigated the mechanisms underlying sepsis- induced s...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-01 | PXD072078 | Pride
Skeletal muscle weakness Sepsis Mitochondria icu-acquired weakness (icu-aw) Β-nmn 
GenomicsNicotinamide Mononucleotide alleviates aging defects of Hutchinson-Gilford progeria syndrome
Nicotinamide Mononucleotide alleviates aging defects of Hutchinson-Gilford progeria syndrome
PRJNA1254259 | ENA
GenomicsNicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes
Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes
PRJNA644537 | ENA
TranscriptomicsEffect of nicotinamide mononucleotide on doxorubicin-induced cardiac injury in mice
Doxorubicin (DOX) is the cornerstone of chemotherapy regimens for many malignancies, but its clinical usage is limited by severe cardiotoxicity. Accumulating evidence suggest that nicotinamide adenine dinucleotide (NAD+) depletion contributes to DOX-induced cardiotoxicity, making NAD+ boosting an ap...
ORGANISM(S): Mus musculus 
2023-06-03 | GSE233644 | GEO
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