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ProteomicsThe dopamine transporter antiports potassium to increase the uptake of dopamine
The dopamine transporter facilitates dopamine reuptake from the extracellular space to terminate neurotransmission. The transporter belongs to the neurotransmitter:sodium symporter family, which includes transporters for serotonin, norepinephrine, and GABA that utilize the Na+ gradient to drive the ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-20 | PXD032663 | Pride
Ms  membrane proteins  mass spectroemetry  hydrogen-deuterium exchange  transporter 
ProteomicsConformational dynamics of the human serotonin transporter during substrate and drug binding
The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatmen...
ORGANISM(S): Homo sapiens (Human) 
2019-05-15 | PXD013750 | Pride
Hdx-ms  protein-ligand interactions  membrane proteins  mass spectrometry 
ProteomicsSubstrate-induced conformational dynamics of the dopamine transporter
The dopamine transporter is a member of the neurotransmitter:sodium symporters (NSSs), which are responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Experimental evidence elucidating the coordinated conformational rearrangeme...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-11-12 | PXD013841 | Pride
Ms  protein-ligand interactions  membrane proteins  mass spectrometry 
TranscriptomicsHuman skeletal muscle biopsies from a 3h IL-6 infusion
Skeletal muscle has been identified as a secretory organ. We hypothesized that IL-6, a cytokine secreted from skeletal muscle during exercise, could induce production of other secreted factors in skeletal muscle. Keywords: Human skeletal muscle time course response to IL-6 infusion IL-6 was infused...
ORGANISM(S): Homo sapiens 
2008-05-27 | E-GEOD-10685 | biostudies-arrayexpress
MetabolomicsUntargeted Metabolomics Reveals a Mild Impact of Remote Ischemic Conditioning on the Plasma Metabolome and α-Hydroxybutyrate as a Possible Cardioprotective Factor and Biomarker of Tissue Ischemia
Remote ischemic conditioning (RIC) is a maneuver by which short non-lethal ischemic events are applied on distant organs or limbs to reduce ischemia and reperfusion injuries caused by e.g. heart attacks. As RIC can be induced using a simple blood pressure cuff e.g. prior to revascularization, it con...
2016-12-20 | MTBLS414 | MetaboLights
UnknownTrans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.
Not available
S-EPMC11829167 | biostudies-literature
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