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ProteomicsLFQ comparison of total cell lysate, lysosomal and plasma membrane fraction of WT and NPC1 KO cells
Superparamagnetic iron oxide nanoparticles (SPIONs) have so far mainly been used as cellular carriers for genes and therapeutic products, while their use in subcellular organelle isolation remains largely underexploited. We engineered surface functionalized SPIONs (Ø 10 nm) that target very distinc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080792 | MassIVE
ProteomicsCritical Period Inhibition of NKCC1 Rectifies Synapse Development and Restores Adult Tactile Response Maps in Fragile X Mice
Qionger He1, Erica D Arroyo2, Samuel N Smukowski3, Jian Xu, Claire Piochon1, Jeffrey N Savas3, Carlos Portera-Cailliau2 and Anis Contractor1,4* 1Department of Physiology & 3Department of Neurology, Northwestern University Feinberg School of Medicine; 2Departments of Neurology and Neurobiology, Davi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000081526 | MassIVE
TranscriptomicsMycobacterium tuberculosis Complex Clinical Isolates exhibit unique gene expression profiles in vitro and inside macrophages
This SuperSeries is composed of the following subset Series: GSE21111: Basal in vitro transcriptomes of Mycobacterium tuberculosis complex (MTC) clinical isolates GSE21112: Intracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside resting murine ma...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-09 | E-GEOD-21114 | biostudies-arrayexpress
ProteomicsNovel surface functionalized superparamagnetic nanoparticles with engineered cellular uptake as a means for intracellular omics
Superparamagnetic nanoparticles (SPMNPs) are appealing for use in organelle isolation strategies. Yet, this potential remains largely unexplored because thus far research has focused on either physicochemical design or on their application in micron-sized beads. For their use in life sciences, the b...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080688 | MassIVE
TranscriptomicsDifferential expression under hypoxia in zebrafish
The local background was subtracted from the fluorescent value of each spot. Feature intensities were extracted from scanned microarray images using GenePix Pro 5.1. (Axon Instruments). The images were visually inspected, and spots from low-quality areas of the array were flagged and excluded from f...
ORGANISM(S): Danio rerio 
2010-05-27 | E-GEOD-2069 | biostudies-arrayexpress
UnknownWnt5a Promotes Lysosomal Cholesterol Egress and Protects Against Atherosclerosis.
Not available
S-EPMC8776607 | biostudies-literature
TranscriptomicsBasal in vitro transcriptomes of Mycobacterium tuberculosis complex (MTC) clinical isolates
This study uses microarray analyses to examine baseline gene expression profiles for Mycobacterium tuberculosis complex clinical isolates relative to reference strain CDC1551 during log phase growth in vitro in 7H9 broth. For this in vitro analyses, log-phase mycobacteria in starter cultures grown t...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-08 | E-GEOD-21111 | biostudies-arrayexpress
TranscriptomicsIntracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside activated murine macrophages
This study uses microarray analyses to examine transcriptional responses of Mycobacterium tuberculosis complex clinical isolates to phagosomal cues encountered inside activated (IFN-gamma+LPS) murine bone marrow-derived macrophages 24hr post-infection. Transcript levels of intracellular mycobacteria...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-09 | E-GEOD-21113 | biostudies-arrayexpress
TranscriptomicsIntracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside resting murine macrophages
This study uses microarray analyses to examine transcriptional responses of Mycobacterium tuberculosis complex clinical isolates to phagosomal cues encountered inside resting murine bone marrow-derived macrophages 24hr post-infection. Transcript levels of intracellular mycobacteria were compared to ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-09 | E-GEOD-21112 | biostudies-arrayexpress
TranscriptomicsSNP array in NPC and ESC from C57BL6xCAST hybrid
Genomic profiling by array to find chromosomic region with aneuploidy in NPC and ESC clones from hybride C57BL5 and CAST mouse
ORGANISM(S): Mus musculus 
2014-02-25 | E-MTAB-1823 | biostudies-arrayexpress
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