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UnknownDevelopment of Focused Ultrasound-Assisted Nanoplexes for RNA Delivery.
RNA-based therapeutics, including siRNA, have obtained recognition in recent years due to their potential to treat various chronic and rare diseases. However, there are still limitations to lipid-based drug delivery systems in the clinical use of RNA therapeutics due to the need for optimization in ...
S-EPMC11243722 | biostudies-literature
UnknownMaturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life.
Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a bi...
S-EPMC6842923 | biostudies-literature
UnknownQuantifying Subresolution 3D Morphology of Bone with Clinical Computed Tomography.
The aim of this study was to quantify sub-resolution trabecular bone morphometrics, which are also related to osteoarthritis (OA), from clinical resolution cone beam computed tomography (CBCT). Samples (n = 53) were harvested from human tibiae (N = 4) and femora (N = 7). Grey-level co-occurrence mat...
S-EPMC6949315 | biostudies-literature
UnknownVolumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy.

Objective

The purpose of this prospective multicenter study was to assess the safety and technical feasibility of volumetric Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) ablation for treatment of patients with symptomatic uterine fibroids.

Methods

Thirty-three...
S-EPMC3249029 | biostudies-literature
UnknownTh1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans.
Upregulation of IL-17 immunity and detrimental effects of IL-17 on human islets have been implicated in human type 1 diabetes. In animal models, the plasticity of Th1/Th17 cells contributes to the development of autoimmune diabetes. In this study, we demonstrate that the upregulation of the IL-17 pa...
S-EPMC4273995 | biostudies-literature
UnknownNew insights into the genetic etiology of Alzheimer's disease and related dementias.
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'pro...
S-EPMC9005347 | biostudies-literature
UnknownRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.

Background

Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with riv...
S-EPMC6662613 | biostudies-literature
UnknownCorrection: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
[This corrects the article DOI: 10.1371/journal.pgen.1005378.].
S-EPMC4927064 | biostudies-literature
UnknownThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially betw...
S-EPMC4591371 | biostudies-literature
UnknownIdentification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously estab...
S-EPMC3696959 | biostudies-literature
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