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UnknownGenome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.

Rationale

A genome-wide association study (GWAS) for circulating chronic obstructive pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker levels and COPD susceptibility.

Objectives

To identify genetic variants of circulating protein biomarkers and novel...
S-EPMC3622441 | biostudies-literature
UnknownThe relationship between the epigenetic aging biomarker "grimage" and lung function in both the airway and blood of people living with HIV: An observational cohort study.

Background

Age-related comorbidities such as chronic obstructive pulmonary disease (COPD) are common in people living with human immunodeficiency virus (PLWH). We investigated the relationship between COPD and the epigenetic age of the airway epithelium and peripheral blood of PLWH.

Metho...

S-EPMC9379521 | biostudies-literature
UnknownA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

Background

Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smo...
S-EPMC4668640 | biostudies-literature
UnknownWhy START? Reflections that led to the conduct of this large long-term strategic HIV trial.
Not available
S-EPMC4347998 | biostudies-literature
UnknownInitiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.

Background

Data from randomized trials are lacking on the benefits and risks of initiating antiretroviral therapy in patients with asymptomatic human immunodeficiency virus (HIV) infection who have a CD4+ count of more than 350 cells per cubic millimeter.

Methods

We randomly assigned ...
S-EPMC4569751 | biostudies-literature
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