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TranscriptomicsExpression profiling reveals novel pathways in the transformation of melanocytes to melanomas. II
Spotted oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma cells...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4576 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal human melanocytes and melanoma cell lines from advanced lesions
Affymetrix oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma ce...
ORGANISM(S): Homo sapiens 
2007-06-22 | E-GEOD-4570 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brown preadipocytes from wild type and IRS knock-out cell lines
Brown preadipocytes were grown to confluence and synchronized by overnight serum starvation. Four independent RNA samples were analyzed from each IRS KO cell line and three independent clones of WT cells were separately analyzed as controls. Splitting of the samples resulted in a total 28 microarr...
ORGANISM(S): Mus musculus 
2007-04-06 | E-CBIL-26 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of preadipocytes of wild type and IRS-1,IRS-2, IRS-3, IRS-4 knock out mice to reveal role of insulin receptor substrates and necdin
Insulin and IGF-1 promote adipocyte differentiation via complex and overlapping signalling networks. Here we used microarray analysis of brown preadipocytes derived from wild-type and insulin receptor substrate (IRS) knockout (KO) animals, which exhibited progressively impaired differentiation, to ...
ORGANISM(S): Mus musculus 
2007-08-04 | E-GEOD-2556 | biostudies-arrayexpress
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