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TranscriptomicsAntioxidants Accelerate Lung Cancer Progression in Mice
Antioxidants are widely used to protect cells from damage induced by reactive oxygen species (ROS). The concept that antioxidants can help fight cancer is deeply rooted in the general population, promoted by the food supplement industry, and supported by some scientific studies. However, clinical tr...
ORGANISM(S): Mus musculus 
2014-01-31 | E-GEOD-52594 | biostudies-arrayexpress
TranscriptomicsGene Expression profiling of Myc-induced lymphomagenesis
The ability of oncogenes to provoke cancer is harnessed by regulators that control cell proliferation or induce apoptosis, and bypass of these checkpoints is a hallmark of malignancies. Myc oncoproteins are overexpressed in ~70% of all cancers and induce numerous transcription targets that regulate ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32239 | biostudies-arrayexpress
TranscriptomicsGenome-wide 5-hydroxymethylcytosine (5hmC) profiling by hMeDIP-seq in primary human CD4+T-cells polarized towards Th1 and Th2 time-series
Differentiation of CD4+T-cells into effector subsets is a critical component of the adaptive immune system and an incorrect response can lead to autoimmunity or immune deficiency. Cellular differentiation including T-cell differentiation is accompanied by large-scale epigenetic remodeling, including...
ORGANISM(S): Homo sapiens 
2016-07-11 | E-MTAB-4686 | biostudies-arrayexpress
UnknownIL-25 inhibits atherosclerosis development in apolipoprotein E deficient mice.
Not available
S-EPMC4309452 | biostudies-literature
ProteomicsAggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis, part 2
Aggregation is a sequence-specific process, nucleated by short aggregation prone regions (APR) that can be exploited to induce aggregation of proteins containing the same APR. Here we find that most APRs are unique within a proteome, but that a small minority of APRs occur in many proteins. When agg...
ORGANISM(S): Escherichia coli 
2018-03-05 | PXD008701 | Pride
E. coli Protein aggregation Inclusion bodies Aggregation prone regions 
UnknownMudPIT profiling reveals a link between anaerobic metabolism and the alkaline adaptive response of Listeria monocytogenes EGD-e.
Not available
S-EPMC3544664 | biostudies-literature
UnknownElectrochemical Genosensing of E. coli Based on Padlock Probes and Rolling Circle Amplification.
Not available
S-EPMC7959471 | biostudies-literature
TranscriptomicsRNA-seq of human uveal melanoma cell lines 92-1, MP41 and UM22 treated with entinostat, JQ1 or DMSO
As part of the preclinical research for a recently published trial of combination therapy with the HDAC inhibitor entinostat and the PD1 inhibitor pembrolizumab, an experiment was performed to determined the influence of entinostat and the BET inhibitor JQ1 on the transcriptome of three uveal melano...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-11058 | biostudies-arrayexpress
UnknownThe Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway.
Not available
S-EPMC5360024 | biostudies-literature
UnknownILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions.
Not available
S-EPMC6905041 | biostudies-literature
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