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ProteomicsHmgb2 improves astrocyte to neuron conversion by Neurog2-dependent increase in accessibility of genes related to neuronal maturation
Direct conversion of reactive glial cells to neurons is promising avenue for the replacement therapies after brain injury or neurodegeneration. The overexpression of developmental neurogenic fate determinants in glial cells converts them to neurons. For the repair purposes the conversion is confined...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-06 | PXD044288 | Pride
Lc-msms Astrocytes Mouse 
TranscriptomicsFunctional dissection of the Paired domain of Pax6 – distinct roles of subdomains in neurogenesis and proliferation
The transcription factor Pax6 acts as a key developmental regulator in various organs. In the developing brain Pax6 regulates patterning, neurogenesis and proliferation, but how these diverse effects are mediated at the molecular level is not well understood. As Pax6 regulates forebrain development ...
ORGANISM(S): Mus musculus 
2013-03-19 | E-GEOD-35260 | biostudies-arrayexpress
TranscriptomicsThe transcriptome of prospectively isolated adult neural stem cells
Since the discovery of adult neural stem cells, their exact identity is still under discussion. Moreover, the lack of a reproducible procedure to purify neural stem cells prospectively rather than by growing them in vitro has so far precluded their study at the transcriptome level. Here we demonstra...
ORGANISM(S): Mus musculus 
2010-11-19 | E-GEOD-18765 | biostudies-arrayexpress
UnknownParkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons
Not available
S-SCDT-EMM-2021-14797 | biostudies-other
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