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Transcriptomic analysis of Nintedanib, Alpelisib and Nintedanib Alpelisib treated bladder tumors
Transcriptomic analysis of Nintedanib, Alpelisib and Nintedanib Alpelisib treated bladder tumors
Nintedanib induces senolytic effect via STAT3 inhibition
The fibro-infammatory progenitors and mesothelial cells were sorted from the epididymal adipose tissue of high fat diet fed mice treated with vehicle or with Nintedanib+celecoxib, and their transcriptomic profiles were performed using RNAseq.
ORGANISM(S): Mus musculus 
Selective removal of senescent cells, or the concept of senolytic therapy, has been proposed to be a potent strategy for overcoming age-related diseases and even reversing aging. We found that nintedanib, a tyrosine kinase inhibitor, selectively induced cell death in primary human diploid fibroblast...
ORGANISM(S): Homo sapiens 
2022-09-06 | GSE210020 | GEO
Nintedanib is a potent anti-fibrotic angio-kinase inhibitor, which has shown clinical efficacy in combination with chemotherapy in locally advanced muscle invasive BC patients. Nintedanib inhibits Fibroblast Growth Factor receptors (FGFRs), validated targets in patients with BC harboring FGFR3/2 gen...
ORGANISM(S): Homo sapiens Mus musculus 
2023-04-13 | GSE182833 | GEO
Nintedanib is a potent anti-fibrotic angio-kinase inhibitor, which has shown clinical efficacy in combination with chemotherapy in locally advanced muscle invasive BC patients. Nintedanib inhibits Fibroblast Growth Factor receptors (FGFRs), validated targets in patients with BC harboring FGFR3/2 gen...
ORGANISM(S): Homo sapiens Mus musculus 
2023-04-13 | GSE218575 | GEO
Nintedanib and Pirfenidone affect growth and differentiation of human alveolar type 2 cells
Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts [miRNA-seq]
Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts [RNA-seq]
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