Sort   by:  
 Page size 
ProteomicsDirect 3D sampling of the embryonic mouse head: Layer-wise nanosecond infrared laser (NIRL) ablation from scalp to cortex for spatially resolved proteomics
Common workflows in bottom-up proteomics require homogenization of tissue samples giving to get access to the biomole-cules within the cells. The homogenized tissue samples often contain many different cell types, thereby representing an average of the natural proteome composition and rare cell type...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD043011 | Pride
Nirl ablation Spatial proteomics Tissue sampling Bottom-up proteomics 
ProteomicsSampling and homogenization of nanoliter tissue with a nanosecond infrared laser (NIRL) for mass spectrometric proteomics
It was recently shown that ultrashort pulse infrared (IR) lasers, operating at the wavelength of the OH vibration stretching band of water, are highly efficient at softly sampling and homogenizing biological tissue. We utilized a nanosecond infrared laser (NIRL) for tissue sampling and homogenizatio...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027700 | Pride
Laser ablation Tissue sampling  nanosecond infrared laser Proteomics  mass spectrometry 
UnknownTissue Sampling and Homogenization in the Sub-Microliter Scale with a Nanosecond Infrared Laser (NIRL) for Mass Spectrometric Proteomics.
Not available
S-EPMC8509473 | biostudies-literature
ProteomicsTissue sampling and homogenization with NIRL enables spatially resolved cell layer specific proteomic analysis of the murine intestine
For investigating the molecular physiology and pathophysiology in organs the most exact data will be obtained, if not organ specific cell lines are analysed or the whole organ is homogenized, followed by the analysis of its biomolecules, but if the morphological organisation of the organ can be addr...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-22 | PXD033584 | Pride
Colon 3d Mouse Laser-ablstion Lc-ms/ms 
UnknownDirect 3D Sampling of the Embryonic Mouse Head: Layer-wise Nanosecond Infrared Laser (NIRL) Ablation from Scalp to Cortex for Spatially Resolved Proteomics.
Not available
S-EPMC10688223 | biostudies-literature
ProteomicsSpatial proteomics reveals distinct protein patterns in a lissencephaly-like cortical migration disorder caused by LIN28A overexpression and WNT activation
Developmental signalling pathways act in stage and tissue dependent relation and mis-activation can drive tumour formation. The RNA-binding protein LIN28A maintains stemness and is overexpressed in embryonal brain tumours. Activating mutations of CTNNB1 - the WNT pathway effector - have been reporte...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD053649 | Pride
Cortical migration disorder Ctnnb1 Spatial proteomics Lin28a 
Sort   by:  
 Page size