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TranscriptomicsLIN28A-mediated regulation of microRNA biogenesis in mouse embryonic stem cell (A3-1) [Agilent]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37112 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling for changes upon Lin28a knockdown in mouse embryonic stem cell (A3-1) [Affymetrix]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37113 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide identification of LIN28A targets in mouse embryonic stem cell (A3-1) [Illumina Seq]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37111 | biostudies-arrayexpress
ProteomicsLIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib Resistance
Chronic myeloid leukemia (CML) resistance to BCR-ABL tyrosine kinase inhibitors (TKIs) can arise from ABL kinase domain mutations, BCR-ABL fusion gene amplification, or kinase-independent mechanisms. To investigate imatinib-resistance, we performed quantitative mass spectrometry comparing the proteo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD066618 | Pride
Imatinib K562 Tki resistance Lin28a Phosphoproteomics 
TranscriptomicsGenome-wide analysis of skeletal muscle gene expression in Lin28A Tg mice
To identify mechanisms involved in growth and glucose metabolism, we performed whole genome mRNA expression analysis in five week old quadraceps muscle from 2 CD-1 background male Lin28A Tg and 2 WT littermates (all male) in which there was 7 fold overexpression of Lin28A, a RNA binding protein that...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-21226 | biostudies-arrayexpress
GenomicsCLIP-Seq for LIN28A or LIN28A loss of function mutant expressing 293FT cells
CLIP-Seq for LIN28A or LIN28A loss of function mutant expressing 293FT cells
PRJNA729718 | ENA
GenomicsRNA-Seq for LIN28A or LIN28A loss of function mutant expressing 293FT cells
RNA-Seq for LIN28A or LIN28A loss of function mutant expressing 293FT cells
PRJNA729719 | ENA
ProteomicsOverexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density
The RNA binding protein LIN28A is a stem- and progenitor marker and one of the factors necessary to induce pluripotent stem cells in vitro. LIN28A has been shown to promote the proliferative capacity of neural progenitor cells but its specific role during embryonal and postnatal brain development st...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028044 | Pride
Lin28a Phosphopetide Etmr Dda dia lc-ms/ms 
ProteomicsLIN28a modulates ESC differentiation by interacting with PRC2
LIN28a is an RNA binding protein that was initially characterized for its role in the negative regulation of let-7 microRNA biogenesis. In the last years a new role in the regulation of mRNA translation has been highlighted. This mechanism seems to be particularly relevant in the exit of embryonic s...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD049332 | Pride
Lin28a Interactome Embryonic stem cells Rna binding protein 
ProteomicsSpatial proteomics reveals distinct protein patterns in a lissencephaly-like cortical migration disorder caused by LIN28A overexpression and WNT activation
Developmental signalling pathways act in stage and tissue dependent relation and mis-activation can drive tumour formation. The RNA-binding protein LIN28A maintains stemness and is overexpressed in embryonal brain tumours. Activating mutations of CTNNB1 - the WNT pathway effector - have been reporte...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD053649 | Pride
Cortical migration disorder Ctnnb1 Spatial proteomics Lin28a 
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