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ProteomicsROS-activated ATM-dependent phospho-signaling
ATM (ataxia-telangiectasia mutated) protein plays a central role in phosphorylating a network of proteins in response to DNA double strand breaks. These phosphorylated proteins function in signalling pathways designed to maintain the stability of the genome and minimize the risk of disease by contro...
ORGANISM(S): Homo sapiens (Human) 
2016-01-04 | PXD002850 | Pride
Reactive oxygen species Atm Fibroblast Phosphoproteomics 
ProteomicsOverexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density
The RNA binding protein LIN28A is a stem- and progenitor marker and one of the factors necessary to induce pluripotent stem cells in vitro. LIN28A has been shown to promote the proliferative capacity of neural progenitor cells but its specific role during embryonal and postnatal brain development st...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028044 | Pride
Lin28a Phosphopetide Etmr Dda dia lc-ms/ms 
ProteomicsIsolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanism neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purification to isolate stable multi-protein complexes of...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021368 | Pride
Kcc2 Phosphorylation Proteome Interactome 
ProteomicsSex and Insulin Resistance Define a Cell Autonomous Supernetwork of Protein Phosphorylation
Insulin resistance is an important factor in the pathophysiology of many metabolic disorders. The aim of this study was to uncover the cell autonomous determinants of insulin resistance using induced pluripotent stem cell (iPSC)-derived myoblasts (iMyos). Here, we found that iMyos from insulin resis...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD022637 | Pride
Sex Insulin resistance Diabetes Insulin signaling Phosphorylation 
ProteomicsA Broad Network of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
Skeletal muscle insulin resistance is the earliest defect in type 2 diabetes (T2D), preceding and predicting disease development. Whether this represents the underlying primary defect in T2D or effects of changes in hormones or circulating metabolites is unknown. To address this question, we have de...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD015430 | Pride
Type 2 diabetes Ipscs Insulin signaling Phosphoproteome 
ProteomicsKinase inhibition rewires the HLA-I immunopeptidome in Chronic Myeloid Leukemia
Antileukemia immunity is essential for disease control and maintaining treatment-free remission in chronic myeloid leukemia (CML). Immunotherapeutic approaches hold significant promise for enhancing immune-mediated disease control. However, successful immunotherapy relies on identifying CML-associat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD076608 | Pride
Kinase inhibitors Immunopeptidomics Proteomics Cml 
ProteomicsRemodeling of the cardiac extracellular matrix proteome during chronological and pathological aging
Impaired extracellular matrix (ECM) remodeling is a hallmark of many chronic inflammatory disorders that can lead to cellular dysfunction, aging, and disease progression. The ECM of the aged heart and its effects on cardiac cells during chronological and pathological aging are relatively poorly unde...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-08 | PXD040234 | Pride
Hutchinson-gilford progeria syndrome Proteomics Left ventricle Lactadherin Extracellular matrix Aging 
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