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ProteomicsKCC2 Proteome - Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
KCC2 is a neuron-specific K+-Cl‑ cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition. KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis and AMPA receptor confinement. Aberrant KCC2 function contributes to numerous hum...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-16 | PXD006046 | Pride
Kcc2 Interacting proteins Cation chloride cotransporter Lc/ms Proteomics Neuronal chloride homeostasis Slc12a5 Gaba E/i balance Glutamate 
ProteomicsGephyrin interacts with the K-Cl co-transporter KCC2 to regulate its surface expression and function in cortical neurons
The K+-Cl- co-transporter KCC2, encoded by the Slc12a5 gene, is a neuron-specific chloride extruder that tunes the strength and polarity of GABAA receptor-mediated transmission. Besides its canonical ion-transport function, KCC2 also regulates spinogenesis and excitatory synaptic function through in...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-29 | PXD022412 | Pride
Synapse Neuron Chloride transport Scaffold protein Interactomics 
GenomicsDisruption of KCC2 in parvalbumin-positive interneurons causes fatal epilepsy in mice
Disruption of KCC2 in parvalbumin-positive interneurons causes fatal epilepsy in mice
PRJEB48759 | ENA
TranscriptomicsDisruption of KCC2 in parvalbumin-positive interneurons causes fatal epilepsy in mice
Since many years, we are interested in the regulation of the intraneuronal chloride concentration. We were the first group reporting a full knockout of the KCl-co-transporter KCC2, which dies immediately after birth due to respiratory failure. Notably, KCC2 loss-of-function mutations are associated ...
ORGANISM(S): Mus musculus 
2022-11-02 | E-MTAB-11147 | biostudies-arrayexpress
UnknownKCC2 downregulation facilitates epileptic seizures.
Not available
S-EPMC5427808 | biostudies-literature
TranscriptomicsNeurodevelopmental ATM deficiency affects glutamatergic transmission through KCC2-KARs expression in the hippocampus but not in the cortex
Interest in the function of ataxia-telangiectasia mutated protein (ATM) is extensively growing as evidenced by preclinical studies which continuously associate ATM loss with new intracellular pathways. To further investigate ATM involvement in neurotransmission, we initially exploited ATM+/- and ATM...
ORGANISM(S): Mus musculus 
2022-07-05 | GSE202217 | GEO
GenomicsNeurodevelopmental ATM deficiency affects glutamatergic transmission through KCC2-KARs expression in the hippocampus but not in the cortex
Neurodevelopmental ATM deficiency affects glutamatergic transmission through KCC2-KARs expression in the hippocampus but not in the cortex
PRJNA835074 | ENA
ProteomicsIsolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanism neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purification to isolate stable multi-protein complexes of...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021368 | Pride
Kcc2 Phosphorylation Proteome Interactome 
UnknownMolecular architecture of potassium chloride co-transporter KCC2.
Not available
S-EPMC5705597 | biostudies-literature
UnknownK+-Cl- cotransporter-2 KCC2 in chicken cardiomyocytes.
Not available
S-EPMC3530769 | biostudies-literature
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