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MetabolomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
2023-01-31 | MTBLS6337 | MetaboLights
MetabolomicsGut metabolome of Trachemys scripta elegans after fecal microbiota transplantation and supplement GABA,Arg in feed.

Extract the intestinal contents of Trachemys scripta elegans subjected to environmental stress at a salinity of ten PSU for 6 months, isolate the gut microbiota, and transplant them into other healthy Trachemys scripta elegans to observe their gut microbiota metabolite. Add GAGA and Arg to the fe...

2025-07-09 | MTBLS12187 | MetaboLights
ProteomicsProteomic and Behavioral Study of the Anxiolytic Effects of GABA in a Chronic Restraint Stress-Induced Anxiety Model
This study aimed to investigate the anxiolytic effects of GABA administration and its underlying molecular mechanisms in a chronic restraint stress (CRS)-induced anxiety model in C57BL/6J mice. CRS mice were established by placing the animals in well-ventilated 50 ml centrifuge tubes for 2 hours dai...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD059153 | Pride
Anxiety Gaba 
ProteomicsGABA, glucose and insulin orchestrate CD4+ T cells effector functions
Metabolic programs of immune cells are closely linked to their effector functions , where physiological molecules provide environmental cues and guidance. Exactly how it happens is still being unraveled. Insulin maintains normal blood glucose levels and glucose is themain source of energy and a prec...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD041654 | Pride
Cd4 Gaba 
ProteomicsB cell-derived GABA elicits IL-10+ macrophages and limits anti-tumor immunity
Small, soluble metabolites are not only essential intermediates in intracellular biochemical processes, but can also influence neighboring cells when released into the extracellular milieu. Here, we identify the metabolite and neurotransmitter GABA as a candidate signaling molecule synthesized and s...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-15 | PXD028403 | Pride
Anti-tumor immunity Macrophages Gaba B cells 
Transcriptomicsler vs pop2-1: gaba over-accumulation effects-Transcriptomic analysis of pop2-1 mutant in Arabidopsis thaliana
au05-03_gaba - ler vs pop2-1: gaba over-accumulation effects - The analysis aims at identifying genes that are differentially regulated by the over-accumulation of GABA observed in the mutant pop2-1 in response to treatment with exogenous GABA and that may explain the singular phenotype of the mutan...
ORGANISM(S): Arabidopsis thaliana 
2009-04-11 | E-GEOD-11129 | biostudies-arrayexpress
ProteomicsProteomic identification of GAP-binding proteins in colorectal cancer reveals PPP1CA as a direct target of microbial GABA-mediated metabolic rewiring
This dataset corresponds to the proteomic analysis presented in Figure 6A of the manuscript “Obesity-driven microbial GABA depletion promotes metabolic rewiring and colorectal cancer progression.” We performed Drug Affinity Responsive Target Stability (DARTS) and co-immunoprecipitation proteomics us...
ORGANISM(S): Homo sapiens (Human) 
2026-06-21 | PXD069744 | Pride
Gaba  gap  ppp1ca 
ProteomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-29 | PXD037901 | Pride
Macrophage Succinate Succinylation Fad Gaba 
TranscriptomicsExpression analysis of superior cervical ganglion from backcrossed TH-MYCN transgenic mice
Neuroblastoma susceptibility in TH-MYN mice is heavily influence by mouse strain background. We have combined linkage analysis of tumor susceptibility with expression QTL analysis of superior cervical ganglia (pure peripheral symptathetic nervous tissue) to identify genes underlying tumor formation...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-59675 | biostudies-arrayexpress
ProteomicsThe leaves of creeping bentgrass (Agrostis stolonifera) LC−ESI−MS/MS
The global emergence of soil salinization poses a serious challenge to many countries and regions. γ-Aminobutyric acid (GABA) is involved in systemic regulation of plant adaptation to salt stress, but the underling molecular and metabolic mechanism still remains largely unknown. The elevated endogen...
ORGANISM(S): Agrostis stolonifera 
2020-01-13 | PXD015066 | Pride
Proteomics Bentgrass Salt stress Lc−esi−ms/ms 
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