Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse preimplantation development
Preimplantation development is a crucial step for successful implantation and pregnancy. Although both compaction and blastocyst formation have been extensively studied, mechanisms regulating early cell division stages before compaction have remained unclear. Here, we show that ERK MAP kinase funct...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7309 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NIH3T3 cell line cultured with and withput FGF and treated with the MEK Inhibitor U0126 at 3 time points before FGF addition reveals ERK-dependent downregulated genes have the ability to block S phase entry
The ERK family of MAP kinase plays a critical role in growth factor-stimulated cell cycle progression from G0/G1 to S phase. But, how sustained activation of ERK promotes G1 progression has remained unclear. Here, our systematic analysis on the temporal program of ERK-dependent gene expression shows...
ORGANISM(S): Mus musculus 
2007-11-24 | E-GEOD-4739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of preimplantation mouse embryos to study the requirement of the MAP kinase signaling pathway for preimplantation development.
We examined expression profiles of genes that could be regulated by the MAPK pathways during mouse preimplantation development. We used Affymetrix GeneChips for microarray analysis, and three independent experiments were carried out. 8-cell stage embryos were treated or untreated with MAPK inhibit...
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2229 | biostudies-arrayexpress
TranscriptomicsThe protein kinase MLTK Is a key regulator for chondrogenesis.
Sox9 acts together with Sox5 or Sox6 as a master regulator for chondrocyte differentiation; however, how these transcription factors functionally interact and collaborate to regulate chondrogenesis remains unclear. Here we show that the protein kinase MLTK plays an essential role in the onset of cho...
ORGANISM(S): Xenopus laevis 
2012-09-04 | E-GEOD-33767 | biostudies-arrayexpress
TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
TranscriptomicsThe Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Downregulating Components of the Death-Inducing Signaling Complex
A balance between cell survival and apoptosis is essential for animal development. Although proper development involves multiple interactions between germ layers, little is known about the intercellular and intertissue signaling pathways that promote cell survival in neighboring or distant germ laye...
ORGANISM(S): Xenopus laevis 
2011-02-21 | E-GEOD-26381 | biostudies-arrayexpress
TranscriptomicsHIRA, a Conserved Histone Chaperone, Plays an Essential Role in Low-dose Stress Response via Transcriptional Stimulation in Fission Yeast
Cells that have been pre-exposed to mild stress (priming stress) acquire transient resistance to subsequent severe stress even under different combinations of stresses. This phenomenon is called cross-tolerance. Although it has been reported that cross-tolerance occurs in many organisms, the molecul...
ORGANISM(S): Schizosaccharomyces pombe 
2012-07-21 | E-GEOD-35281 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Caenorhabditis elegans under dietary restriction
Dietary restriction (DR) is the most effective and reproducible intervention to extend lifespan in divergent species1. In mammals, two regimens of DR, intermittent fasting (IF) and caloric restriction (CR), have proven to extend lifespan and reduce the incidence of age-related disorders2. An impor...
ORGANISM(S): Caenorhabditis elegans 
2009-01-13 | E-GEOD-9682 | biostudies-arrayexpress
TranscriptomicsIdentification and characterization of retinoic acid-responsive genes in mouse kidney development
Retinoic acid (RA) signaling regulates a variety of developmental processes through controlling the expression of numerous genes. Here, we have identified and characterized RA-responsive genes in mouse kidney development. Analysis of isolated embryonic kidneys cultured in the presence and absence of...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-57656 | biostudies-arrayexpress
TranscriptomicsA conserved JNK/AP-1 module is a key mediator of intermittent fasting-induced longevity in C. elegans
Dietary restriction extends lifespan and delays the age-related physiological decline in many species. Intermittent fasting (IF) is one of the most effective dietary restriction regimens that extends lifespan in C. elegans and mammals1,2. In C. elegans, the FOXO transcription factor DAF-16 is implic...
ORGANISM(S): Caenorhabditis elegans 
2013-03-15 | E-GEOD-27677 | biostudies-arrayexpress
Sort   by:  
 Page size