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MetabolomicsEndoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants
Brassicaceae plants have a dual-cell type of chemical defense against herbivory. Here we show a novel single-cell defense involving endoplasmic reticulum (ER)-derived organelles (ER bodies) and the vacuoles. We identify various glucosinolates as endogenous substrates of the ER-body β-glucosidases BG...
2020-02-04 | MTBLS1383 | MetaboLights
UnknownComparison of peg-interferon, ribavirin plus telaprevir vs simeprevir by propensity score matching.
Not available
S-EPMC4670956 | biostudies-literature
TranscriptomicsHCT 116 cells expressing Fucci (fluorescent ubiquitination-based cell cycle indicator); G1 phase vs. S/G2/M phase
Fucci-expressing HCT116 were inoculated into subcutaneous tissue or cecum of NOD/SCID mice. Four weeks after inoculation, Fucci green (mAG; S/G2/M) and red (mKO2;G1) expressing cells were isolated from implanted tumors by FACSAria sorting (BD, Biosciences). Comparative analyses among green and red c...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-34940 | biostudies-arrayexpress
TranscriptomicsExpression data of NIH3T3 in G0 and G1 phases
NIH3T3 in the middle of G0 to G1 transion consists of the cells which is still staying G0 phase and the cells which enters G1. Monitoring the expressions of p27 and Cdt1 enables to distinguish these two; p27+/Cdt1+ cells as the cells in G0 phase and p27-Cdt1+ cells as G1 phase We sorted p27+Cdt1+ (...
ORGANISM(S): Mus musculus 
2014-02-21 | E-GEOD-46511 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression levels in BBF2H7-/- chondrocytes
BBF2H7 (BBF2 human homolog on chromosome 7), an ER-resident basic leucine zipper transcription factor, is activated in response to ER stress and abundantly expresses in chondrocytes. While BBF2H7 is widely expressed in many tissues and organs, the most intense signals were detected in the proliferat...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-18052 | biostudies-arrayexpress
TranscriptomicsThe G1 arrest and maintenance mechanism between the long-term G1-arrested and the G1-arrested cells.
Non mitotic tumor cells are resistant to conventional chemotherapeutic drugs. However, the mechanisms underlying this phenomenon remain unclear. Here, we found a population that is viable but remains in the G1 phase for an extended period of time (up to 48 h) by Long-term time-lapse observations in ...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-61088 | biostudies-arrayexpress
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