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MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsComparison of root transcriptomes in Arabidopsis thaliana plants supplied with different forms of inorganic nitrogen
Plants aquire nitrogen from the soil, most commonly in the form of either nitrate or ammonium. Unlike ammonium, nitrate must be reduced (with NADH and ferredoxin as electron donors) prior to assimilation. Thus, nitrate nutrition imposes a substantially greater energetic cost than ammonium nutrition....
ORGANISM(S): Arabidopsis thaliana 
2011-05-28 | E-GEOD-29589 | biostudies-arrayexpress
TranscriptomicsIdentification of genes induced on nitrate, role of OxyR
The study aimed to identify role of OxyR during growth on different electron acceptors when E. coli are growing anaerobically. Wt and OxyR null cells were grown on nitrate and fumarate medium anaerobically. Each condition was done in duplicate. RNA was extracted using Qiagen RNeasy kit after stabili...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2012-05-02 | E-GEOD-24524 | biostudies-arrayexpress
Transcriptomicsuranyl nitrate exposure
SAGE analysis in kidney obtained from control mice or after acute or chronic exposure to uranyl nitrate (UN). Keywords: other
ORGANISM(S): Mus musculus 
2004-06-10 | E-GEOD-1465 | biostudies-arrayexpress
TranscriptomicsImpact of NRT1.1 point mutants on gene expression under high NH4NO3 supply
NRT1.1 is a nitrate transceptor involved in many nitrate responses including the regulation of gene expression through (i) the Primary Nitrate Response (PNR) and (ii) the regulation the NRT2.1 gene under continuous high NH4NO3 conditions. Phosphorylation of NRT1.1’s T101 residue is involved in the m...
ORGANISM(S): Arabidopsis thaliana 
2015-01-15 | E-GEOD-49437 | biostudies-arrayexpress
ProteomicsPhosphoproteome profiling under low nitrate and high nitrate in Arabisopsis wild type roots
In this project, we treated Arabidopsis wild type (Col-0) with low nitrate (0.2 mM KNO3) and high nitrate (5 mM KNO3) after nitrate starvation. Next we harvested root, and then we performed memebrane fraction and cytosolic fraction isolation for trypsin digestion and phosphopeptide enrichment.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-21 | PXD014146 | Pride
Phosphoproteomics Nitrate signaling 
ProteomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
ORGANISM(S): Homo sapiens (Human) 
2026-05-20 | PXD076314 | Pride
Nitrate  sialin2  er-mitochondria contacts  calcium signaling  lipid mobilization  adipose browning 
MetabolomicsGestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
Dysregulated maternal fatty acid metabolism increases the risk of congenital heart disease (CHD) in offspring with an unknown mechanism, and the effect of folic acid fortification in preventing CHD is controversial. Using gas chromatography coupled to either a flame ionization detector or mass spect...
2023-03-24 | MTBLS6982 | MetaboLights
TranscriptomicsOleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide mediate signaling in plant defense.
Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide- mediate signaling in plant defense. Nitric Oxide, Oleic acid, Salicylic acid, Arabidopsis, Defense Wild-type Col-0, mutant genotypes ssi2, ssi2 act1 and ssi2 sid2 with three biological replicates were...
ORGANISM(S): Arabidopsis thaliana 
2012-07-31 | E-GEOD-36797 | biostudies-arrayexpress
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