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TranscriptomicsTranscription profiling of human NK cells sorted into CD56dim and CD56bright NK cell subpopulations
Human NK cells were sorted into CD56dim and CD56bright NK cell subpopulations. In order to define characteristics of both populations gene profiling was performed using Affymetrix arrays U133a and U133B.
ORGANISM(S): Homo sapiens 
2006-05-31 | E-MEXP-380 | biostudies-arrayexpress
TranscriptomicsCellular senescence reprograms human NK cells to promote vascular remodeling
Natural killer (NK) cells are lymphocytes that participate in immune responses through their cytotoxic activity and secretion of cytokines and chemokines. They can be activated by interaction with ligands on target cells or by soluble mediators such as cytokines. In addition, soluble HLA-G, a major ...
ORGANISM(S): Homo sapiens 
2012-12-03 | E-GEOD-35330 | biostudies-arrayexpress
ProteomicsSARS-CoV2 manipulates multiple NK ligands and inhibits NK activation, but this can be overcome by ADNKA, which is strongly activated by non-Spike targeting antibodies
SARS-CoV2 is recognised the antagonise the interferon response, and functioning interferon responses are critical in determining the severity of disease. However, whether the virus antagonises cellular immunity has not been determined. We used quantitative plasma membrane proteomics in lung epitheli...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD025000 | Pride
Sars-cov2 Nk ligands Adnka 
TranscriptomicsIFN alpha-induced gene expression in human NK cells
NK cells are believed to contribute to the control of hepatitis C virus infection and pathogenesis of liver disease. Standard treatment of both acute and chronic hepatitis C is based on the administration of interferon alpha, however, the effects of type I interferons on human NK cells have not been...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-15743 | biostudies-arrayexpress
TranscriptomicsDecidual NK cells Xiong et al 2013
Receptors of the KIR family on maternal Natural Killer cells in the decidua are believed to bind to Ligands such as HLA-C on trophoblast cells invading into the decidua from the placenta during early pregnancy. The resulting responses regulate the extent of trophoblast invasion. Genetic studies have...
ORGANISM(S): Homo sapiens 
2014-04-04 | E-MTAB-1784 | biostudies-arrayexpress
TranscriptomicsExpression data from activated NK cells [RNA]
Natural Killer (NK) cells present natural cytotoxicity against tumor cells, although their activity is increased after activation. NK cell activation depends on a complex intracellular signaling process mediated by activating and inhibitory receptors and the functional outcome depends on the integra...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-50838 | biostudies-arrayexpress
TranscriptomicsExpression data from activated NK cells [miRNA]
Natural Killer (NK) cells present natural cytotoxicity against tumor cells, although their activity is increased after activation.NK cell activation depends on a complex intracellular signaling process mediated by activating and inhibitory receptors and the functional outcome depends on the integrat...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-50839 | biostudies-arrayexpress
GenomicsSurfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing
Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing
PRJNA1450573 | ENA
GenomicsiPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors
iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors
PRJNA877281 | ENA
TranscriptomicsMicroarray analysis of resting Nkrp1g+ NK cells versus resting Nkrp1g- NK cells from spleens of female BALB/c mice.
Natural Killer Gene Complex (NKC)-encoded immunomodulatory C-type lectin-like receptors (CTLR) include members of the NKRP1 and CLEC2 gene families, which constitute genetically linked receptor-ligand pairs and are thought to allow for NK cell-mediated immunosurveillance of stressed or infected tiss...
ORGANISM(S): Mus musculus 
2017-11-21 | E-MTAB-6223 | biostudies-arrayexpress
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