Sort   by:  
 Page size 
MetabolomicsMolecular Docking and Dynamic Study of Ethanol Extract of Citrus sinensis as Keap-1 and NMDA inhibitor in Brain Injury

Traumatic brain injury is a significant cause of mortality in young adults and disability in all age groups. Secondary injury involving various processes such as oxidative stress, which induced neuronal apoptosis, ensued afterward. This study aimed to analyze the active compounds of Citrus sinens...

2023-01-02 | MTBLS5785 | MetaboLights
TranscriptomicsTranscription profiling of mouse hippocampal slices after NMDA or forskolin-rolipram-0 Mg2+ or bicuculline treatment
Effect of different chemical stimuli (NMDA(N-methyl-D-aspartic acid), forskolin/rolipram/0 Mg, bicuculline) on gene expression after 1 h of stimulation in hippocampal slices
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1184 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
TranscriptomicsStudy the effect of mesenchymal stem cells on isolated cortical neurons before and after NMDA treatment
Primary cortical neurons were isolated from E15 mice and after 5 days in vitro were untreated or treated for 24 h with mesenchymal stem cell conditioned medium and then untreated or treated for a further 24 h with NMDA. Neuron gene expression was profiled and compared between the four different cond...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-26279 | biostudies-arrayexpress
TranscriptomicsRegulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for Histone Deacetylase 4
Gene expression analysisis of NR2A and NR2B containing NMDA receptors after treatment with AP5, NVP-AAM077 and Ro25-6981 4 conditions, vehicle, AP5, Ro25, and NVP, 4-5 replicates of each sample
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-54708 | biostudies-arrayexpress
GenomicsGLP-1 directed NMDA receptor antagonism for obesity treatment [II]
GLP-1 directed NMDA receptor antagonism for obesity treatment [II]
PRJNA1029627 | ENA
GenomicsGLP-1 directed NMDA receptor antagonism for obesity treatment [I]
GLP-1 directed NMDA receptor antagonism for obesity treatment [I]
PRJNA1023883 | ENA
TranscriptomicsPRR7 is a novel NMDA-dependent inhibitor of c-Jun ubiquitination in neurons
Elevated c-Jun levels result in apoptosis and are evident in neurodegenerative disorders such as Alzheimer's disease and dementia and after global cerebral insults such as stroke and epilepsy. NMDA receptor (NMDAR) antagonists block c-Jun upregulation and prevent neuronal cell death following excito...
ORGANISM(S): Rattus norvegicus 
2014-10-25 | E-GEOD-62686 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat embryos at 11 days in culture treated at 10, 30, 60, 180, 360, min with 1 mM NMDA vs. neuronal cultures
Nicotinic receptors (nAChR) are widely distributed in the adult brain where they mediate excitatory postsynaptic transmission and presynaptic release of other neurotransmitters. Functional nicotinic receptors are also present in the embryonic brain. Several studies have suggested a role for nAChRs i...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4242 | biostudies-arrayexpress
GenomicsNMDA receptor positive allosteric modulator induced genome wide gene expression changes in neuronal cultures
NMDA receptor positive allosteric modulator induced genome wide gene expression changes in neuronal cultures
PRJNA578282 | ENA
Sort   by:  
 Page size