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TranscriptomicsNOD2 and desease associated variant NOD2-L1007fsinsC dependent genomewide transcriptional regulation in stable Flp-In HEK cells
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide (MDP) and variants of NOD2 are associated with chronic inflammatory diseases of barrier organs e.g. Crohn disease, asthma and atopic eczema. It is known that activation of NOD2 induces a variety of inflammatory...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-22611 | biostudies-arrayexpress
TranscriptomicsNOD2 transmissible microbiota predispose WT mice to inflammation
Instability in the composition of gut bacterial communities, referred as dysbiosis, has been associated with important human intestinal disorders such as Crohn’s disease and colorectal cancer. Our data showed that Nod2-mediated risk of intestinal inflammation in colitis model is communicable to WT m...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-36481 | biostudies-arrayexpress
TranscriptomicsNOD2-dependent licensing of the microbiota predispose to transmissible inflammation and tumorigenesis in the colon.
Instability in the composition of gut bacterial communities, referred as dysbiosis, has been associated with important human intestinal disorders such as CrohnM-bM-^@M-^Ys disease and colorectal cancer. Here, we show that dysbiosis coupled to Nod2 or Rip2 deficiency suffices to cause an increased ri...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-32421 | biostudies-arrayexpress
ProteomicsValosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses
To detect novel NOD2 interaction partners in the context of IBD, immunoprecipitates from wildtype NOD2 and mutant NOD2 with IBD-causing variants were analyzed using LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2025-03-05 | PXD031539 | Pride
Human Nod2 Immunoprecipitation 
ProteomicsMDP phosphorylation by NAGK is essential for NOD2 activation
Bacterial cell wall components provide various unique molecular structures that are detected by pattern recognition receptors (PRRs) of the innate immune system as non-self. Most bacterial species form a cell wall that consists of peptidoglycan, a polymeric structure comprising of alternating amino ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-13 | PXD022384 | Pride
Nagk Sugar kinase Inflammation Muramyl dipeptide Nod2 Bacterial sensing 
GenomicsNOD2 influences intestinal resilience
NOD2 influences intestinal microbial resilience after antibiotic perturbation
PRJEB21817 | ENA
GenomicsNOD2 genotype microbiota study
The impact of NOD2 variants on fecal microbiota in Crohn’s disease and healthy controls
PRJEB21593 | ENA
GenomicsEstrogen Impacts NOD2-Dependent Regulation of Intestinal Homeostasis
Estrogen Impacts NOD2-Dependent Regulation of Intestinal Homeostasis
PRJNA1273181 | ENA
GenomicsDraft genome sequence of Frankia sp. Dg1 Dg nod2
Draft genome sequence of Frankia sp. Dg1 Dg nod2
PRJEB19447 | ENA
ProteomicsDistinct Colitis-Associated Macrophages Drive NOD2-Dependent Bacterial Sensing and Gut Homeostasis
Single-cell studies have revealed that intestinal macrophages maintain gut homeostasis through the balanced actions of reactive (inflammatory) and tolerant (non-inflammatory) subpopulations. How such balance is impaired in inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerat...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-23 | PXD066180 | Pride
Proteomics Gut homeostasis Tmt10 Bacterial sensing 
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