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TranscriptomicsGene expression in blastomeres after transfer of somatic cells into human oocytes
The exchange of the oocyte's genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cell types affected in degenerative human diseases. Such cells, carrying the patient's genome, might be useful for cell replacement. H...
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-28022 | biostudies-arrayexpress
UnknownCRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.
Not available
S-EPMC5660456 | biostudies-literature
TranscriptomicsAn Automated, High Platform for Induced Pluripotent Stem Cell Derivation, Characterization and Differentiation
Induced pluripotent stem cells (iPSCs) have become an essential tool for both modeling how causal genetic variants impact cellular function in disease, as well as being an emerging source of tissue for transplantation medicine. Unfortunately the preparation of somatic cells, their reprogramming and ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-69868 | biostudies-arrayexpress
UnknownNovel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.
Not available
S-EPMC12187977 | biostudies-literature
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