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MetabolomicsAn LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

INTRODUCTION: Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H2) ...

2021-10-06 | MTBLS2418 | MetaboLights
ProteomicsCochlear Proteomics: Insights into the Auditory Pathophysiology
Hearing loss (HL) is a global disability caused by irreversible damage to cochlear hair cells, essential for sound transduction. In mammals, the inability to regenerate these cells results in permanent auditory deficits. Early postnatal mice exhibit a limited regenerative potential from supporting c...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-05 | PXD058223 | Pride
Noise-induced hearing loss Omics data reuse Sensory epithelium regeneration Cochlear proteomics Auditory pathophysiology Nano lc-ms/ms 
GenomicsCochlear single-cell gene expression profiles in mice with noise-induced hidden hearing loss and noise-induced hearing loss.
Cochlear single-cell gene expression profiles in mice with noise-induced hidden hearing loss and noise-induced hearing loss.
PRJNA1059254 | ENA
ProteomicsApoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway
The purpose of this study is to investigate the therapeutic effect of MSC-derived apoVs treatment on NIHL and the potential mechanism of resisting oxidative stress damage in hair cells, as well as the distribution of apoptotic vesicles in the inner ear. The study provided a new direction for the tre...
ORGANISM(S): Homo Sapiens 
2023-03-20 | PXD040989 |
GenomicsBrimonidine protects IHC ribbon synapses and SGNs from noise-induced hearing loss
Brimonidine protects IHC ribbon synapses and SGNs from noise-induced hearing loss
PRJNA1320646 | ENA
TranscriptomicsCochlear single-cell gene expression profiles in mice with noise-induced hidden hearing loss and noise-induced hearing loss.
Noise-induced hidden hearing loss (HHL) is a new type of hearing loss that has been identified in recent years and leads to insidious damage to the cochlea, unlike the well-known noise-induced hearing loss (NIHL). However, the cellular and molecular basis for it remains to be elucidated. Here, we es...
ORGANISM(S): Mus musculus 
2024-06-24 | GSE252285 | GEO
GenomicsTherapeutic Restoration of miR-96 Prevents Hearing Loss in Mice through Modulation of Noise-Induced and Genetic Pathways
Therapeutic Restoration of miR-96 Prevents Hearing Loss in Mice through Modulation of Noise-Induced and Genetic Pathways
PRJNA1038749 | ENA
TranscriptomicsBrimonidine protects IHC ribbon synapses and SGNs from noise-induced hearing loss
Exposure to excessive noise levels can result in hearing impairment. Currently, there are no effective pharmacological interventions available for the prevention of noise-induced hearing loss. This study was designed to investigate the protective effects of brimonidine, an α2-adrenergic receptor ago...
ORGANISM(S): Mus musculus 
2026-04-15 | GSE307393 | GEO
UnknownNoise-induced hearing loss in farmworkers: a scoping review.
Not available
S-EPMC11913118 | biostudies-literature
GenomicsHeat-Shock Pathway Activation by TRC-051384 Protects Spiral Ganglion Neurons from Noise-Induced Hearing Loss [Spatial Transcriptomics]
Heat-Shock Pathway Activation by TRC-051384 Protects Spiral Ganglion Neurons from Noise-Induced Hearing Loss [Spatial Transcriptomics]
PRJNA1375652 | ENA
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