Sort   by:  
 Page size 
MetabolomicsSearching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug, ...
2021-02-08 | MTBLS873 | MetaboLights
ProteomicsProteome of silenced minichromosome maintenance protein 2 with siRNA on non-small cell lung cancer H1299 cells
Lung cancer is the leading cause of cancer-related mortality. The two main lung cancer types are small cell lung cancer (SCLC) and non-SCLC (NSCLC), where NSCLC comprises about 80-85% of all lung cancer. Despite the introduction of improved treatments, the overall survival rate of lung cancer patien...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003743 | Pride
Non small cell lung cancer h1299 cells Rna interference Proteome Minichromosome maintenance protein 2 Itraq Lc-ms/ms 
TranscriptomicsIdentification of genes differentially expressed in lung cancer cells after the transfection of miR-221 or miR-222.
To evaluate involvement of miR-221 and miR-222 in lung cancer, we investigated the effects of miR-221 and miR-222 overexpression on six lung cancer cell lines as well as one immortalized normal human bronchial epithelial cell line. Two cell lines, H3255 and H1299 with no replicates were studied. Ce...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-57676 | biostudies-arrayexpress
TranscriptomicsExpression data in H1299 after retinoblastoma binding protein-2 (RBP2) knockdown
To identify genes whose expression was affected by RBP2, we performed gene expression microarray analysis in control and RBP2 depletion human lung cancer cell line. Two individual shRNA (RBP2 KD1 and RBP2 KD2) were used to limit potential off-target effects. One scramble short haripin RNA (shRNA) an...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-41443 | biostudies-arrayexpress
ProteomicsCRTAC1 Enhances the Chemosensitivity of Non-Small Cell Lung Cancer to Cisplatin by Eliciting RyR-mediated Calcium Release and Inhibiting Akt1 Expression
Sensitivity to platinum-based combination chemotherapy is associated with a favorable prognosis in the patients of non-small cell lung cancer (NSCLC). Here, our results obtained from analyses of the Gene Expression Omnibus database of NSCLC patients showed that cartilage acidic protein 1 (CRTAC1) pl...
ORGANISM(S): Homo sapiens (Human) 
2023-08-29 | PXD041782 | Pride
Non-small cell lung cancer  chemosensitivity  crtac1  akt1  ca2+ 
TranscriptomicsExpression data for cultured NCI-H1299 parental and spheroid cells as well as their derived xenograft models
Current approaches to the preclinical investigation for novel cancer therapies rely heavily on the use of traditional cancer cell lines maintained in serum-containing conditions. The discrepancy between promising preclinical efficacy and clinical outcome of most novel anticancer agents emphasizes a ...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-21612 | biostudies-arrayexpress
Proteomicshuman lung adenocarcinoma cell lines TMT based proteomics
In our study, we found that profilin 1 (PFN1) promoted non-small cell lung cancer (NSCLC) metastasis.For further investigate the mechanisms of PFN1's roles in NSCLC metastasis, we constructed PFN1 overxpression H1299 cell lines(H1299 PFN1 OE cells). And we sent samples of H1299 PFN1 OE cells and EV ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD033148 | Pride
Lung adenocarcinoma cell line Tmt Human 
TranscriptomicsRNA sequencing of non–small cell lung cancer (NSCLC) cell line H1299 following chloroquine (CQ) treatment
Functional lysosomes are essential for tumor growth. CQ, a widely used lysosome inhibitor, has been combined with various other therapeutics for testing in cancer patients. However, no studies have reported enhanced antitumor effects from these treatments. To investigate how tumor cells survive CQ-m...
ORGANISM(S): Homo sapiens 
2025-12-05 | E-MTAB-16126 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung cancer cells treated with 5-aza - a genome-wide screen for hypermethylated genes in lung cancer
Abstract; Background: Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are init...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5816 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
Sort   by:  
 Page size