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Investigation of protein phosphorylation in humans has largely focussed on serine (Ser), threonine (Thr) and tyrosine (Tyr), with proven roles for these modifications in all aspects of life. However, mounting evidence suggests that phosphorylation of non-canonical amino acids, including histidine an...
ORGANISM(S): Homo sapiens (Human) 
2020-06-16 | PXD012188 | Pride
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation
The hereditary spastic paraplegia type 21 (SPG21) protein is a RAB7A effector that promotes non-canonical mTORC1-catalyzed TFEB phosphorylation and cytoplasmic retention
G protein-coupled receptors (GPCRs) are typically characterized by their seven transmembrane (7TM) architecture, and interaction with two universal signal-transducers namely, the heterotrimeric G-proteins and β-arrestins (βarrs). Synthetic ligands and receptor mutants have been designed to elicit tr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027887 | Pride
Molecular basis of non-canonical stop codon recognition by mtRF1 in human mitochondria
Gene expression profiling of extranodal nasal-type NK/T cell lymphoma and other EBV-associated lymphoid proliferation disease patients was analyzed to elucidate association between JAK-STAT pathway and canonical or non-canonical PRC2/EZH2 target pathways using Illumina HumanRef-8 v3 chips. In total,...
ORGANISM(S): Homo sapiens 
Protein N-phosphorylation enrichment is faced with great difficulties due to the intrinsic instability of the N-P bond, which has seriously hindered its biological function unraveling. Current methods for N-phosphopeptides enrichment are challenging to fulfil high selectivity for all types of N-phos...
ORGANISM(S): Homo Sapiens Escherichia Coli Mus Musculus 
2024-12-12 | PXD058797 |
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