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ProteomicsCooperative clamp-mediated promoter recognition by poxviral RNA polymerase and its TBP/TFIIB-like partner
The recruitment of RNA polymerase (RNAP) to gene promoters is a critical step in gene expression. For RNAP II, this process is initiated by the TATA-box binding protein (TBP) and transcription factor IIB (TFIIB), with homologs of these TBP/TFIIB pairs found in all known multi-subunit RNAP systems. H...
ORGANISM(S): Vaccinia virus Homo sapiens (Human) 
2025-12-17 | PXD065561 | Pride
Vaccinia virus Clamp-loading Tbp/tfiib-like Cryo-electron microscopy Pre-initiation complex Non-canonical promoter recognition Transcription initiation 
UnknownZinc-finger transcription factor Fzf1 binds to its target DNA in a non-canonical manner.
Not available
S-EPMC12852955 | biostudies-literature
UnknownA non-canonical multisubunit RNA polymerase encoded by the AR9 phage recognizes the template strand of its uracil-containing promoters.
Not available
S-EPMC5449584 | biostudies-literature
UnknownStructure of the bacteriophage PhiKZ non-virion RNA polymerase bound to a p119L open promoter analogue.
Not available
S-EPMC12809450 | biostudies-literature
UnknownIntrinsically disordered regions facilitate target search to drive promoter selectivity by a yeast transcription factor.
Not available
S-EPMC12804832 | biostudies-literature
UnknownFOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.
Not available
S-EPMC9410875 | biostudies-literature
UnknownCrystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter.
Not available
S-EPMC5443350 | biostudies-literature
UnknownPolymorphic potential of SRF binding site of c-Fos gene promoter: in vitro study.
Not available
S-EPMC11613138 | biostudies-literature
TranscriptomicsA new type of pathogenic transcription factor mutation targeting interferon regulatory factor 4 (IRF4) in human lymphoma
We report the characterization of a recurrent somatic mutation c.295T>C (p.C99R) in the Interferon Regulatory Factor 4 (IRF4) gene in human lymphoma in the α3-recognition helix of the IRF4 DNA-binding domain. IRF4-C99R fundamentally alters IRF4 DNA-binding, combining loss-of-binding at canonical IRF...
ORGANISM(S): Mus musculus 
2023-07-21 | E-MTAB-12522 | biostudies-arrayexpress
UnknownNucleotide sequence conservation of novel and established cis-regulatory sites within the tyrosine hydroxylase gene promoter.
Not available
S-EPMC4354813 | biostudies-literature
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