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TranscriptomicsThe conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells
Different from canonical ubiquitin-like proteins, Hub1 does not form covalent conjugates with substrates but binds proteins non-covalently. In Saccharomyces cerevisiae, Hub1 associates with spliceosomes and mediates alternative splicing of SRC1, without affecting pre-mRNA splicing generally. Human H...
ORGANISM(S): Homo sapiens 
2014-05-30 | E-GEOD-56878 | biostudies-arrayexpress
ProteomicsNon-canonical splicing junctions between exons and transposable elements represent a source of immunogenic recurrent neo-antigens in cancer patients
ost characterized tumor antigens are ‘genomic’, i.e. encoded by canonical, non-canonical or somatically mutated genomic sequences. We investigate here the presentation and immunogenicity of tumor antigens derived from non-canonical mRNA splicing events between coding exons and transposable elements ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD034820 | Pride
Transposable element Human Non-canonical splicing Neoantigen Immunopeptidomics 
GenomicsTransposable element exonization by non-canonical splicing generates a diversity reservoir of functional protein isoforms
Transposable element exonization by non-canonical splicing generates a diversity reservoir of functional protein isoforms
PRJNA980573 | ENA
ProteomicsCell-specific non-canonical amino acid labelling identifies changes in the hippocampal de novo proteome during memory formation
The formation of spatial long-term memory (LTM) requires the de novo synthesis of distinct sets of proteins; however, a non-biased examination of the de novo proteome in this process is lacking. Here, we generated a novel mouse strain, which enables cell-type-specific labelling of newly synthesised ...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD015820 | Pride
Long-term memory Non-canonical amino acid labelling Azidohomoalanine Azidonorleucine Swath Active place avoidance Protein synthesis Mrna splicing 
GenomicsSF3B1 association with chromatin determines splicing outcomes
Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. Part of the explanation probably lies in differences in chromatin organization between exons and introns. Pro...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-65644 | biostudies-arrayexpress
GenomicsThe conserved Prp40 WW domains facilitate non-canonical intron splicing via bridging 5'-splice-site and branch-site interaction
The conserved Prp40 WW domains facilitate non-canonical intron splicing via bridging 5'-splice-site and branch-site interaction
PRJNA1331766 | ENA
UnknownSplicing Dysregulation of Non-Canonical GC-5' Splice Sites of Breast Cancer Susceptibility Genes ATM and PALB2.
Not available
S-EPMC11545216 | biostudies-literature
TranscriptomicsHP1 is involved in regulating the global impact of DNA methylation on alternative splicing
The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we found that DNA methylation can act both as an enhancer and as a silencer of splicing, and affects the splicing of more than 20...
ORGANISM(S): Mus musculus 
2015-03-08 | E-GEOD-64910 | biostudies-arrayexpress
UnknownIdentification of motifs that function in the splicing of non-canonical introns.
Not available
S-EPMC2481429 | biostudies-literature
UnknownAll reported non-canonical splice site variants in GLA cause aberrant splicing.
Not available
S-EPMC10432374 | biostudies-literature
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