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MetabolomicsCharacterization of active peptides derived from three leeches and comparison of their anti-thrombotic mechanisms using the tail vein thrombosis model in mice and metabonomics

BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real mater...

2024-01-18 | MTBLS9306 | MetaboLights
MetabolomicsAlleviation of high-fat diet-induced lipid metabolism disorders: Role of quinoa peptides in inhibiting high-activity BSH-producing gut microbiota and modulating of BA-FXR/TGR5 signaling
Abstract Background: Lipid metabolism disorders contribute significantly to various metabolic diseases and are closely related to gut microbiota dysbiosis. Our previous study showed that oral gavage of quinoa peptides (QPep) restored gut microbiota composition and alleviated liver lipid metabolism d...
2025-06-16 | MTBLS12584 | MetaboLights
ProteomicsDiscovery and quantification of non-human proteins in human milk
The question whether and which non-human peptides or proteins are present in human milk was raised many decades ago. However, due to cross-reactivity or nonspecific antibody recognition, the accuracy of detection by immunochemical methods has been a concern. Additionally, the relative low-abundance ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Felis catus (Cat) (Felis silvestris catus) Canis familiaris (Dog) (Canis lupus familiaris) Gallus gallus (Chicken) Oryza sativa (Rice) Equus caballus (Horse) 
2018-12-04 | PXD011599 | Pride
Non-human peptides Shotgun proteomics Human milk Mass spectrometry Non-human proteins Parallel reaction monitoring 
ProteomicsDiscovery and quantification of non-human proteins in human milk
The question whether and which non-human peptides or proteins are present in human milk was raised many decades ago. However, due to cross-reactivity or nonspecific antibody recognition, the accuracy of detection by immunochemical methods has been a concern. Additionally, the relative low-abundance ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Felis catus (Cat) (Felis silvestris catus) Canis familiaris (Dog) (Canis lupus familiaris) Gallus gallus (Chicken) Oryza sativa (Rice) Equus caballus (Horse) 
2020-11-04 | PXD010413 | Pride
Non-human peptides Shotgun proteomics Human milk Mass spectrometry Non-human proteins Parallel reaction monitoring 
MetabolomicsTransgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance
The emergence of multidrug-resistant pathogens poses a significant threat to human health and agriculture. Current antimicrobial strategies against phytopathogens are often ineffective, failing to ensure food security while contributing to environmental pollution. Synthetic antimicrobial peptides (A...
2025-09-25 | MTBLS12255 | MetaboLights
TranscriptomicsNovel antioxidative peptides with potential to reduce psoriatic changes in PBMCs
Oxidative damage contributes significantly to the pathogenesis of psoriasis. We recently developed antioxidative peptides (UPF peptides) activating the endogenous glutathione system (GSH). In the present study, we analyzed gene expression profiles in the samples of psoriasis patients to find if thes...
ORGANISM(S): Homo sapiens 
2012-08-22 | E-GEOD-40263 | biostudies-arrayexpress
ProteomicsA Hidden Human Proteome Encoded by the “Non-Coding” Genes
It has been a long debate whether the 98% “non-coding” fraction of human genome can encode functional proteins besides a “random noise” of translation. We used our established translatome sequencing (RNC-seq) to analyze human cells and found that up to 3330 long non-coding RNAs (lncRNAs) were bound ...
ORGANISM(S): Homo Sapiens 
2019-08-29 | PXD044056 |
TranscriptomicsEffect of phenylalanine-rich peptide on growth and survival of Mycobacterium tuberculosis H37Rv (Mtb)
During our efforts to isolate potantial binding partners of Esat6, we isolated few peptides rich in phenylalanine residues that strongly interacted with Esat6. All peptides were less than fifty amino acids in length, One of them, Hcl1, when expressed in mycobacteria showed significant retardation in...
ORGANISM(S): Mycobacterium tuberculosis 
2009-11-10 | E-GEOD-16618 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+ T cells induced by HIV-1 gp120/V3 loop peptides, time series
Comparative changes of gene expression in human primary CD4+ T cells induced by HIV-1 gp120/V3 loop synthetic peptides, during antigen presentation
ORGANISM(S): Homo sapiens 
2008-09-01 | E-MEXP-1586 | biostudies-arrayexpress
TranscriptomicsResponse of peripheral blood mononuclear cells to influenza virus, human cytomegalovirus, and candida albicans derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 1 healthy donor. The cells w...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72371 | biostudies-arrayexpress
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