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ProteomicsNon-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles
Several mechanisms are known to cause monomeric protein misfolding. Coarse-grained simulations have predicted an additional mechanism exists involving off-pathway, non-covalent lasso entanglements, which are long-lived kinetic traps and structurally resemble the native state. Here, we examine whethe...
ORGANISM(S): Escherichia coli 
2025-08-11 | PXD066083 | Pride
Structural mass spectrometry Non-native entanglement 
UnknownNon-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles.
Not available
S-EPMC12333692 | biostudies-literature
ProteomicsProtein misfolding involving entanglements provides a structural explanation for the origin of stretched-exponential refolding kinetics
Stretched-exponential protein refolding kinetics, first observed decades ago, were attributed to a nonnative ensemble of structures with parallel, non-interconverting folding pathways. However, the structural origin of the large energy barriers preventing interconversion between these folding pathwa...
ORGANISM(S): Escherichia coli 
2025-03-18 | PXD053582 | Pride
Folding Crosslinking mass spectrometry Stretched-exponential kinetics 
ProteomicsProtein misfolding involving entanglements provides a structural explanation for the origin of stretched-exponential refolding kinetics
Stretched-exponential protein refolding kinetics, first observed decades ago, were attributed to a nonnative ensemble of structures with parallel, non-interconverting folding pathways. However, the structural origin of the large energy barriers preventing interconversion between these folding pathwa...
ORGANISM(S): Escherichia coli 
2025-03-18 | PXD053579 | Pride
Limited proteolisys mass spectrometry Stretched-exponential kinetics Refolding 
ProteomicsUniversal protein misfolding intermediates can bypass the proteostasis network and remain soluble and non-functional
Using coarse-grain molecular dynamics simulations of the synthesis, termination, and post-translational dynamics of a representative set of cytosolic E. coli proteins, we predict that half of all proteins exhibit subpopulations of misfolded conformations that are likely to bypass molecular chaperone...
ORGANISM(S): Escherichia coli 
2022-04-13 | PXD031425 | Pride
Proteostasis Protein misfolding 
UnknownIt is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs.
Not available
S-EPMC10931463 | biostudies-literature
UnknownFolding kinetics of an entangled protein.
Not available
S-EPMC10681328 | biostudies-literature
UnknownProtein misfolding involving entanglements providesa structural explanation for the origin of stretched-exponential refolding kinetics.
Not available
S-EPMC11908495 | biostudies-literature
UnknownSynonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements.
Not available
S-EPMC11260358 | biostudies-literature
TranscriptomicsTop1 and Top2-mediated replication fork integrity
DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are recruited on replicating chromosomes and how their inactivation affects fork integrity and DNA damage checkpoint activation. We show that, in the context of replicating chroma...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-8305 | biostudies-arrayexpress
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