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MetabolomicsBiosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters in Actinobacteria
A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemica...
2017-07-18 | MTBLS454 | MetaboLights
MetabolomicsMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NR...
2021-06-22 | MTBLS2313 | MetaboLights
GenomicsA niche-derived non-ribosomal peptide triggers planarian sexual development.
A niche-derived non-ribosomal peptide triggers planarian sexual development.
PRJNA1113555 | ENA
ProteomicsUnderstanding condensation domain selectivity in non-ribosomal peptide biosynthesis: structural characterization of the acceptor bound state
Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a peptide bond between two peptidyl carrier protein (PCP)...
ORGANISM(S): Escherichia coli 
2021-04-07 | PXD024015 | Pride
Non-ribosomal peptide  biosynthesis  condensation domain  peptidyl carrier protein  biocatalysis 
ProteomicsUnderstanding condensation domain selectivity in non-ribosomal peptide biosynthesis: structural characterization of the acceptor bound state
Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a peptide bond between two peptidyl carrier protein (PCP)...
ORGANISM(S): Escherichia coli 
2021-05-28 | PXD024004 | Pride
Non-ribosomal peptide  biosynthesis  condensation domain  peptidyl carrier protein  biocatalysis 
GenomicsA male-derived non-ribosomal peptide pheromone controls female schistosome development II
A male-derived non-ribosomal peptide pheromone controls female schistosome development II
PRJNA789552 | ENA
TranscriptomicsA niche-derived non-ribosomal peptide triggers planarian sexual development.
Germ cells are regulated by local microenvironments (niches), which secrete instructive cues. Conserved developmental signaling molecules act as niche-derived regulatory factors, yet other types of niche signals remain to be identified. Single-cell RNA-sequencing of sexual planarians revealed niche ...
ORGANISM(S): Schmidtea mediterranea 
2024-06-06 | GSE267865 | GEO
GenomicsA male-derived non-ribosomal peptide pheromone controls female schistosome development
A male-derived non-ribosomal peptide pheromone controls female schistosome development
PRJNA766647 | ENA
TranscriptomicsMOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The recent identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of addi...
ORGANISM(S): Homo sapiens 
2015-03-07 | E-GEOD-65068 | biostudies-arrayexpress
ProteomicsDecreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling
Tau is a scaffolding protein which serves multiple cellular functions that are perturbed in neurodegenerative diseases, including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). We have recently shown that amyloid-, the second hallmark of AD, induces de novo protein synthesis of tau. Imp...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-17 | PXD013341 | Pride
Tauopathy Non-canonical amino acid labelling Neurodegenerative disease. Protein synthesis Ribosomal proteins 
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