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MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
ProteomicsSite-specific incorporation of two noncanonical amino acids in GFP
Site-specific incorporation of two noncanonical amino acids for two-color bioorthogonal labeling and chemical-controlled crosslinking of proteins on live mammalian cells
ORGANISM(S): Mus Musculus (mouse) 
2020-06-11 | PXD019411 | JPOST Repository
ProteomicsMachine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, most of ncAA-containing protein yields remain low due to the limited activity of PylRS variants. Here, we apply machine learning (ML) to engineer the tRNA-binding domain of P...
ORGANISM(S): Escherichia coli 
2025-07-25 | PXD065336 | Pride
Lc-ms Sfgfp Noncanonical amino acids 
ProteomicsRecoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids
Expanding the genetic code has revolutionized our ability to study and manipulate biological systems through site-specific incorporation of noncanonical amino acids (ncAAs). However, current methods are primarily limited to single-type ncAA incorporation in mammalian cells owing to translation ineff...
ORGANISM(S): Homo Sapiens 
2025-11-04 | PXD070277 |
ProteomicsNoncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing globally in recent years. The development of immunotherapies for colon cancer is critical for providing new treatment strategies to combat drug resistanc...
ORGANISM(S): Escherichia coli 
2026-01-12 | PXD069482 | Pride
Bispecific antibody Maldi-tof Noncanonical amino acid 
UnknownGenetic Incorporation of Noncanonical Amino Acids Using Two Mutually Orthogonal Quadruplet Codons.
Not available
S-EPMC6525065 | biostudies-literature
UnknownNoncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis.
Not available
S-EPMC11467907 | biostudies-literature
UnknownEnhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids.
Not available
S-EPMC6426444 | biostudies-literature
UnknownRecombinant thiopeptides containing noncanonical amino acids.
Not available
S-EPMC4822594 | biostudies-literature
UnknownRationally evolving tRNAPyl for efficient incorporation of noncanonical amino acids.
Not available
S-EPMC4678846 | biostudies-literature
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