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GenomicsThe Dynamic Architecture of Hox Gene Clusters
The spatial and temporal control of Hox gene transcription is essential for patterning the vertebrate body axis. Although this process involves changes in histone posttranslational modifications, the existence of particular three-dimensional (3D) architectures remained to be assessed in vivo. Using ...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-31570 | biostudies-arrayexpress
TranscriptomicsVariegated gene expression caused by cell-specific long-range DNA interactions
Mammalian genomes contain numerous DNA elements with potential transcription regulatory function but unknown target genes. We used transgenic, gain-of-function mice with an ectopic copy of the beta-globin locus control region (LCR) to better understand how regulatory elements dynamically search the ...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-24614 | biostudies-arrayexpress
GenomicsDrosophila melanogaster 4C-Seq experiments in whole embro and mesoderm cells during embryogenesis
Chromosome conformation capture (4C-Seq) in Drosophila Twist-H2B embryos (carrying nuclear tag specifically in the mesoderm) during embryogenesis was performed, anchoring on 107 different viewpoints. Two timepoints (3-4hrs and 6-8hrs after egg laying) and two tissue context (whole embryo and mesoder...
ORGANISM(S): Drosophila melanogaster 
2014-06-26 | E-MTAB-2180 | biostudies-arrayexpress
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