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ProteomicsThe histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo
Histones are essential for chromatin packaging and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited. Therefore, soluble histones must be buffered by histone chaperones but the ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-02-23 | PXD036809 | Pride
Histone Nasp H3-h4 Histone chaperone Ip-ms 
Proteomics1 Identification of replisome-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry
Replication of the eukaryotic genome requires the assembly of thousands of replisomes that must work in concert to accurately replicate a cell’s genetic and epigenetic information. Defining replisome-associated proteins is a key step in understanding how genomes are replicated and repaired in the co...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-01-27 | PXD031165 | Pride
Dna replication Embryogenesis Drosophila Genome stability Replication fork 
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