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ProteomicsThe histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo
Histones are essential for chromatin packaging and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited. Therefore, soluble histones must be buffered by histone chaperones but the ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-02-23 | PXD036809 | Pride
Histone Nasp H3-h4 Histone chaperone Ip-ms 
TranscriptomicsC. elegans nasp-1 / btr-1 mutant versus wild-type N2, exposed to pathogen Bacillus thuringiensis DB27
Transcriptional profiling of C. elegans nasp-1 / btr-1 mutant worms versus wild type N2 strain, both exposed to the bacterial pathogen Bacillus thuringiensis DB27. One-condition experiment. C. elegans nasp-1 / btr-1 mutant versus N2, exposed to Bacillus thuringiensis DB27. 3 biological replicates, i...
ORGANISM(S): Caenorhabditis elegans 
2013-01-31 | E-GEOD-43905 | biostudies-arrayexpress
GenomicsNASP modulates histone turnover to drive PARP inhibitor resistance
NASP modulates histone turnover to drive PARP inhibitor resistance
PRJEB86492 | ENA
GenomicsNASP modulates histone turnover to drive PARP inhibitor resistance
NASP modulates histone turnover to drive PARP inhibitor resistance
PRJNA1244778 | ENA
ProteomicsNASP modulates histone turnover to drive PARP inhibitor resistance
PARP inhibitors (PARPi) present a remarkable advance in the treatment of patients with homologous recombination (HR)-deficient tumors1-3, however resistance remains a challenge due to genomic instability4,5. While most research has focused on the downstream consequences of PARPi exposure to tackle r...
ORGANISM(S): Homo sapiens (Human) 
2025-07-29 | PXD061071 | Pride
Lc-msms Nasp Parp inhibitor Human 
TranscriptomicsGENE PROFILING AND PATHWAY ANALYSIS OF NASP EXPRESSION IN HELA CELLS
Background NASP (Nuclear Autoantigenic Sperm Protein) is a linker histone chaperone required for normal cell division. Changes in NASP expression significantly affect cell growth and development; loss of gene function results in embryonic lethality. However, the mechanism by which NASP exerts its ef...
ORGANISM(S): Homo sapiens 
2009-08-24 | GSE14972 | GEO
GenomicsNASP modulates histone turnover to drive PARP inhibitor resistance
NASP modulates histone turnover to drive PARP inhibitor resistance (Repli-Atac data)
PRJEB90052 | ENA
UnknownMolecular evolution of NASP and conserved histone H3/H4 transport pathway.
Not available
S-EPMC4082323 | biostudies-literature
UnknownNASP functions in the cytoplasm to prevent histone H3 aggregation during early embryogenesis.
Not available
S-EPMC12424855 | biostudies-literature
UnknownNASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes.
Not available
S-EPMC9122598 | biostudies-literature
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