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TranscriptomicsDicer deficiency reveals microRNAs predicted to control gene expression in developing adrenal cortex [RT-PCR]
MicroRNAs (miRNAs) are small, endogenous, non-protein coding RNAs that are an important means of post-transcriptional gene regulation. Deletion of Dicer, a key miRNA processing enzyme, is embryonic lethal in mice, and tissue-specific Dicer deletion results in developmental defects. Using a condition...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45810 | biostudies-arrayexpress
TranscriptomicsAdrenal gene expression profiles of male and female Kcnk3 null mice in basal conditions or after hormonal treatment.
Primary aldosteronism (PA) is a common form of endocrine hypertension suspected in the presence of arterial hypertension (HT), hypokalemia and low plasma renin levels. While for a long time the genetic causes of PA have remained mysterious, recent findings have revealed an important role for an alte...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-37825 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adrenocortical carcinomas (33), adenomas (22), and normal adrenal cortex (10)
Human samples of 33 adrenocortical carcinomas, 22 adrenocortical adenomas, and 10 normal adrenal cortex samples, each from a different patient, had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. Experiment Overall Design: Two supplementary files are attached bel...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-10927 | biostudies-arrayexpress
TranscriptomicsDicer deficiency reveals microRNAs predicted to control gene expression in developing adrenal cortex
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45812 | biostudies-arrayexpress
TranscriptomicsAdrenocortical Carcinoma Gene Expression Profiling [Agilent]
Adrenocortical carcinoma (ACC) is an aggressive endocrine tumor with a poor 5 year survival rate of 10-20%. We used expression profiling to assess the transcriptional changes associated with ACC as compared to normal adrenal glands with the goal of identifying new targets for treatment. Fourteen A...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-19775 | biostudies-arrayexpress
TranscriptomicsAdrenocortical Carcinoma Gene Expression Profiling [Affymetrix]
Background: Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data prognostic biomarkers and novel therapeutic targets. Methods: 44 ACC and 4 normal adrenal glands were profiled on Affymetrix U133 Plus 2 ex...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-19750 | biostudies-arrayexpress
TranscriptomicsExpression data from normal adrenal gland and aldosterone-producing adenoma
The source of aldosterone in 30 to 40 % of patients with primary hyperaldosteronism (PA) is unilateral aldosterone-producing adenoma (APA). The mechanisms causing elevated aldosterone production in APA are unknown. Herein, we examined expression of G-protein coupled receptors (GPCR) in APA and demon...
ORGANISM(S): Homo sapiens 
2007-07-18 | E-GEOD-8514 | biostudies-arrayexpress
ProteomicsProteomic Profile of Human Benign and Malignant Adrenocortical Neoplasia.
The molecular pathogenesis of adrenocortical diseases, particularly adrenocortical carcinoma (ACC), has advanced considerably in recent years due to the application of high-throughput molecular analysis. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) offers an approach for identifying and...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD062822 | Pride
Human adrenal gland Adrenocortical tumors Adrenocortical carcinoma Normal adrenal cortex Adrenocortical adenona Primary macronodular adrenocortical hyperplasia 
GenomicsReal-time quantitative PCR miRNA expression data of normal foetal adrenal neuroblasts and cortex cells, neuroblastoma tumors and embryonic stem cells
Real-time quantitative PCR miRNA expression data of normal foetal adrenal neuroblasts and cortex cells, neuroblastoma tumors and embryonic stem cells
PRJNA497525 | ENA
TranscriptomicsDicer deficiency reveals microRNAs predicted to control gene expression in developing adrenal cortex [array]
MicroRNAs (miRNAs) are small, endogenous, non-protein coding RNAs that are an important means of post-transcriptional gene regulation. Deletion of Dicer, a key miRNA processing enzyme, is embryonic lethal in mice, and tissue-specific Dicer deletion results in developmental defects. Using a condition...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45592 | biostudies-arrayexpress
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