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TranscriptomicsExpression data from oral squamous cell carcinoma (OSCC)-derived cell lines and normal oral keratinocytes
Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a result of local invasion and regional lymph node metastases. We used microarrays to identify down or upregulated genes in OSCCs compared with non-malignant controls. To identify genes whose transcription is d...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-31853 | biostudies-arrayexpress
TranscriptomicsSerum-Mediated Responses in Normal and Transformed Oral Keratinocyte Lines
Serum-driven responses, many of which are related to wound healing, are potentially deregulated in cancer development and associated genomic alterations might have prognostic value. The current study assessed fetal bovine serum-induced transcriptomic changes for clinical relevance in head and neck s...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-39376 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal and transformed buccal keratinocytes
Normal and two transformed buccal keratinocyte lines were cultured under a standardized condition to explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein level. An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-sc...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7862 | biostudies-arrayexpress
TranscriptomicsDiverse routes to oral cancer differing in genome instability and risk for cervical node metastasis
Clinically evident oral lesions, oral epithelial dysplasia, precede development of oral squamous cell carcinomas (SCC) and are considered to transform to cancer by acquisition of genetic or epigenetic alterations. Here, we show that, +3q24-qter, -8pter-p23.1, +8q12-q24.2 and +20 are early events id...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-28407 | biostudies-arrayexpress
TranscriptomicsGene expression profilings of normal human oral keratinocyte (HOK) and dysplastic oral keratinocyte cell line from a heavy smoker (DOK)
In our previous study, we identified global genetic and epigenetic aberrations in the tumors of oral squamous cell carcinoma (OSCC) patients who were habitual smokers. We hypothesized that cigarette smoke might play a role in oral malignant transformation. DOK cell line is a dysplasitc oral keratino...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-54861 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of head and neck squamous cell carcinoma cell lines and normal oral keratinocyte cell lines
Cultured head and neck squamous cell carcinoma cells and normal oral keratinocyte cells were examined for gene expression profiles.
ORGANISM(S): Homo sapiens 
2012-06-20 | E-MEXP-3660 | biostudies-arrayexpress
TranscriptomicsComparative analysis of mouse oral cancer cell lines
A comparative microarray analysis of indolent or aggressive mouse oral cancer cell lines was performed to identify gene expression signatures and specific molecules involved in aggressive tumor growth. We compared 3 indolent cell lines (MOC1, MOC22, MOC23) to 1 aggressive line and it's derivatives ...
ORGANISM(S): Mus musculus 
2014-04-13 | E-GEOD-50041 | biostudies-arrayexpress
TranscriptomicsSerum miRNA profiles of patients with oral cancer and pre-cancer
The aim of this study was to examine the expression profiles of circulating miRNAs in the serum of patients with high-risk oral lesions (HRLs; oral cancer or carcinoma in situ) and to explore their utility as potential oral cancer biomarkers. Global serum miRNA profiles were generated by quantitativ...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-GEOD-37472 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in oral keratinocytes
This was a hypothesis generating experiment to look at miR expression in a range of oral keratinocytes, including normal, precancer and oral cancer samples. The cells were cultures as per standard protocols (duplicate cultures) before assessment on the Affy miRNA array (1.0) one normal oral keratin...
ORGANISM(S): Homo sapiens 
2013-11-28 | E-GEOD-52811 | biostudies-arrayexpress
TranscriptomicsGene expression profilings of normal human oral keratinocyte (HOK) and dysplastic oral keratinocyte cell line from a heavy smoker (DOK)
In our previous study, we identified global genetic and epigenetic aberrations in the tumors of oral squamous cell carcinoma (OSCC) patients who were habitual smokers. We hypothesized that cigarette smoke might play a role in oral malignant transformation. DOK cell line is a dysplasitc oral keratino...
ORGANISM(S): Homo sapiens 
2015-12-31 | GSE54861 | GEO
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