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ProteomicsProteomic profiling during normothermic perfusion predicts liver graft quality and outcomes after transplantation
This study investigates the proteomic dynamics of human liver grafts during normothermic machine perfusion (NMP), using mass spectrometry-based analysis. A total of 16 donor livers were perfused with NMP and sampled at three distinct time points to assess molecular changes and their association with...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD067270 | Pride
Quantitative proteomics Graft viability Normothermic machine perfusion Biliary complications Liver transplantation 
ProteomicsTISSUE AND URINARY PROTEOMIC ANALYSIS OF KIDNEYS UNDERGOING SHORT PERIOD OF NORMOTHERMIC MACHINE PERFUSION.
To identify the main biological effects of the normothermic machine perfusion (NMP) in marginal kidneys, we measured, by mass spectrometry analysis, changes in the proteomic profile of kidney tissues and urines of eight organs reconditioned for 120 minutes (by a Kidney Assist device). Biopsy specime...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD036432 | Pride
Normothermic machine perfusion Proteomics Mass spectrometry Urines Kidney 
GenomicsGene expression profiling of human livers during normothermic machine perfusion
Gene expression profiling of human livers during normothermic machine perfusion
PRJNA1098409 | ENA
GenomicsTranscriptomic analysis of Kidney Machine normothermic perfusion and comparision to cold storage
Transcriptomic analysis of Kidney Machine normothermic perfusion and comparision to cold storage
PRJNA497370 | ENA
GenomicsPan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ischemia-reperfusion injury
Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ischemia-reperfusion injury
PRJNA836578 | ENA
GenomicsMechanisms and treatment of cold-storage-induced microvascular obstructions in normothermic machine perfusion of human kidney
Mechanisms and treatment of cold-storage-induced microvascular obstructions in normothermic machine perfusion of human kidney
PRJNA578096 | ENA
ProteomicsUrine recirculation prolongs normothermic kidney perfusion for via more optimal metabolic homeostasis – a proteomics study
We describe a proteomics analysis to determine the molecular differences between normothermically perfused (normothermic machine perfusion, NMP) human kidneys with urine recirculation (URC) and urine replacement (UR). Proteins were extracted from 16 kidney biopsies with URC (n=8 donors after brain d...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD021507 | Pride
Proteomics Mass spectrometry Nephrology Kidney transplantation Ischemia reperfusion injury Organ perfusion Iri 
ProteomicsProtein Expression in Liver Tissue and Bile of Elderly Sprague-Dawley Rats after Normothermic Machine Perfusion
Liver are frequently declined for transplantation due to the donor age. It is still unclear how donor age affects the graft quality. Normothermic machine perfusion (NMP) has been proposed as a useful assessment tool prior to transplantation. We aimed to compare the performance of young and elderly r...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-08-09 | PXD045394 | Pride
Bile Rat Liver 
TranscriptomicsMechanisms and treatment of cold-storage-induced microvascular obstructions in normothermic machine perfusion of human kidney
Human kidneys which were accepted for transplantation and subsequently not used were subjected to ex vivo normothermic machine perfusion. During perfusion it was found the tubular epithelia synthesized fibrinogen which led to red blood cell aggregation and pathologic plugging of renal microvasculatu...
ORGANISM(S): Homo sapiens 
2022-10-01 | GSE139017 | GEO
ProteomicsTherapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers
Liver transplantation is the only curative option for end-stage liver disease. Donor shortages necessitate the use of higher risk donor livers, including fatty livers, which are more susceptible to ischemia reperfusion injury. Machine perfusion has improved graft utilization and is typically perform...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD056736 | Pride
Proteomics Transplant Hyperthermia Liver Machine perfusion 
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