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MetabolomicsFrom maternal metabolome to placental development: thiamine-driven placental Notch-PI3K/AKT pathway coordinates placental angiogenesis and nutrient transport
Maternal supplementation with thiamine during gestation and lactation promotes placental development and enhances offspring growth through activation of the Notch signaling pathway.
2025-07-30 | MTBLS12796 | MetaboLights
TranscriptomicsChIP-chip from DmD8 cells with Twist antibodies after 30 minutes Notch activation
The transcription factor Twist is a critical cooperating factor that confers transcriptional specificity to the Notch pathway in muscle progenitor cells (DmD8) ChIP analysis of Twi show that Twist binding is significantly enriched in Notch responsive region in DmD8 cells 3 replicates of Twist ChIP a...
ORGANISM(S): Drosophila melanogaster 
2010-07-27 | E-GEOD-22650 | biostudies-arrayexpress
TranscriptomicsPerturbation of the Notch pathway in Xenopus laevis embryos
The Notch signaling pathway functions in a number of processes during embryologic development, especially the maintenance or aquisition of cell fate. We purturb the Notch signalling pathway in embryonic Xenopus laevis in order to 1) better characterize the downstream targets of Notch signalling, and...
ORGANISM(S): Xenopus laevis 
2014-08-06 | E-GEOD-60127 | biostudies-arrayexpress
TranscriptomicsLinking Notch signaling to ischemic stroke
Using a hitherto uncharacterized knockout mouse model of Notch 3, a Notch signaling receptor paralogue highly expressed in vascular SMCs, we uncover a striking susceptibility to ischemic stroke upon challenge. Cellular and molecular analyses of vascular SMCs derived from these animals associate Notc...
ORGANISM(S): Mus musculus 
2014-06-11 | E-GEOD-58368 | biostudies-arrayexpress
TranscriptomicsNotch targets in KC Drosophila cells
To identify genes upregulated in response to Notch signalling in KC cells. Keywords: Expression analysis at a single timepoint (30' after Notch activation) KC cells were obtained from Dr Martin Zeidler. Control versus Notch activated KC cells: mRNA was extracted from KC cells incubated in the absenc...
ORGANISM(S): Drosophila melanogaster 
2010-06-23 | E-GEOD-9965 | biostudies-arrayexpress
TranscriptomicsDynamic binding of RBPJ is determined by Notch signalling status
Notch signalling plays crucial roles in mediating cell fate choices in all metazoans largely by specifying the transcriptional output of one cell in response to a neighbouring cell. The DNA-binding protein RBPJ is the principle effector of this pathway in mammals and together with the transcription ...
ORGANISM(S): Mus musculus 
2013-05-13 | E-GEOD-37184 | biostudies-arrayexpress
TranscriptomicsTargeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the notch pathway
Human oncogenes involved in the development of hematological malignancies have been widely used to model experimental leukemia. Here, we used the fli1 promoter in zebrafish to target the expression of oncogenic HRAS to endothelial cells, including the hemogenic endothelium and observed the developme...
ORGANISM(S): Danio rerio 
2013-09-19 | E-GEOD-41988 | biostudies-arrayexpress
TranscriptomicsGenome wide profiling of Su(H) [CSL] binding in Drosophila melanogaster larval CNSs where Notch is hyperactive in neuroblasts for 24 hours
The Notch pathway is a well conserved cell to cell communication mechanism that is normally involved in many developmental processes and when aberrantly activated it leads to diseases such as cancer. One such example is the neural stem cell tumours that arise from constitutive Notch activity in Dros...
ORGANISM(S): Drosophila melanogaster 
2015-12-15 | E-GEOD-68614 | biostudies-arrayexpress
ModelsSivakumar2011 - Notch Signaling Pathway
Sivakumar2011 - Notch Signaling Pathway Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade. It plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species and the misregulati...
2024-09-02 | BIOMD0000000396 | BioModels
TranscriptomicsActivation of Notch1 and Notch3 Skews Human Airway Basal Cell Differentiation Toward a Secretory Pathway
Airway basal cells (BC) function as progenitor cells capable of differentiating into ciliated and secretory cells to replenish the airway epithelium during physiological turnover and repair. The objective of this study was to define the role of Notch signaling in regulating human airway BC different...
ORGANISM(S): Homo sapiens 
2015-04-13 | E-GEOD-53537 | biostudies-arrayexpress
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