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MetabolomicsFrom maternal metabolome to placental development: thiamine-driven placental Notch-PI3K/AKT pathway coordinates placental angiogenesis and nutrient transport
Maternal supplementation with thiamine during gestation and lactation promotes placental development and enhances offspring growth through activation of the Notch signaling pathway.
2025-07-30 | MTBLS12796 | MetaboLights
ProteomicsOligomerization, trans-reduction, and instability of mutant NOTCH3 in inherited vascular dementia
Cerebral small vessel disease (SVD) is a prevalent disease of aging and a major contributor to stroke and dementia. The most commonly inherited SVD, CADASIL, is caused by dominantly acting cysteine-altering mutations in NOTCH3. These mutations change the number of cysteines from an even to an odd nu...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031097 | Pride
Cadasil Disulfides Notch3 
TranscriptomicsIndraccolo_Notch3
Notch3 expression was analyzed in 20 patients suffering from colorectal carcinoma (CRC) and their corresponding colonic normal (NC) tissue.
ORGANISM(S): Homo sapiens 
2011-05-18 | E-MEXP-3188 | biostudies-arrayexpress
TranscriptomicsNOTCH3 knockdown in non-transformed human esophageal cells
To determine the role of NOTCH3 in human esophageal epitheila homeostasis/squamous cell differentiation Zinc finger E-box binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in transforming growth factor (TGF)-β-mediated epithelial to mesenchymal transition (EMT), senescence an...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-27424 | biostudies-arrayexpress
TranscriptomicsExpression data from caudal artery of Notch3WT and Notch3KO mice
Notch3 is a transmembrane receptor which is critically important for the structure and myogenic response of distal arteries, particularly cerebral arteries. After activation of the receptor, the intracellular domain translocates in the nucleus to activate target genes transcription. In order to iden...
ORGANISM(S): Mus musculus 
2012-03-30 | E-GEOD-36437 | biostudies-arrayexpress
TranscriptomicsNOTCH3 is a master-regulator of motility in neuroblastoma and is essential for cell survival
Migratory embryonal neuroblasts give rise to several tissues, including the sympathetic nervous system (SNS). Neuroblastomas are paediatric tumours of the peripheral SNS with a highly variable prognosis. We observed that high NOTCH3 expression in neuroblastomas correlated with a poor prognosis. Expr...
ORGANISM(S): Homo sapiens 
2013-08-06 | E-GEOD-16477 | biostudies-arrayexpress
TranscriptomicsRole of Notch receptors in ozone induced lung injury in mice
Ozone is a highly toxic air pollutant and global health concern. Mechanisms of genetic susceptibility to ozone-induced lung inflammation are not completely understood. We hypothesized Notch3 and Notch4 are important determinants of susceptibility to ozone-induced lung inflammation. Wild type (WT)...
ORGANISM(S): Mus musculus 
2015-02-24 | E-GEOD-58244 | biostudies-arrayexpress
ProteomicsNOTCH3 missense variants cause familial partial lipodystrophy
Molecular defects in some ultra-rare subtypes of familial lipodystrophies remain unidentified. We identified novel NOTCH3 heterozygous variants in familial partial lipodystrophy (FPL) pedigrees. All variants were clustered in the heterodimerization domain of the negative regulatory region of NOTCH3....
ORGANISM(S): Human 
2024-10-28 | MSV000096235 | MassIVE
GenomicsAccumulation of Notch3 extracellular domain and not aberrant NOTCH3 signaling is the key driver of CADASIL arterial pathology
Accumulation of Notch3 extracellular domain and not aberrant NOTCH3 signaling is the key driver of CADASIL arterial pathology
PRJNA1014747 | ENA
GenomicsNotch3 ChIP-sequencing of brain mural cells differentiated from human pluripotent stem cell-derived neural crest via Notch3 activation
Notch3 ChIP-sequencing of brain mural cells differentiated from human pluripotent stem cell-derived neural crest via Notch3 activation
PRJNA844105 | ENA
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