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TranscriptomicsBulk RNA-seq of cerebral organoids investigating the role of CHD8 in cortical development
We used cerebral organoids generated from wildtype and CHD8 +/- human ES cells to study the effects of CHD8, one of the top ASD risk genes, on early cortical development. CHD8 +/- hESC were generated using the CRISPR/Cas9 system to create a deletion within the helicase domain. Cerebral organoids wer...
ORGANISM(S): Homo sapiens 
2022-02-01 | E-MTAB-9933 | biostudies-arrayexpress
MetabolomicsLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically-...
2023-03-28 | MTBLS6578 | MetaboLights
ProteomicsCullin 3 Mouse Brain TMT-based Proteomics Analysis
This project consists in 3 datasets: - Samples from adult mouse brains (Hippocampus, Cortex and Cerebellum): Cul3 +/- or +/+; 5 animals per condition. - Samples from embryonic mouse cortex: either Cul3 +/- or +/+ - Samples from embryonic mouse cortex: Cul3 fl/fl Emx-1-Cre ("hom"); Cul3 +/fl Emx1-Cre...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-26 | PXD017040 | Pride
Mouse brain cullin 3 cul3 autism cortex cerebellum hippocampus embryonic adult tmt dda high ph rp 
ProteomicsLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically ...
ORGANISM(S): Mus Musculus 
2023-02-09 | PXD038454 |
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