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TranscriptomicsTranscriptional profiling of wild type Neurospora crassa cells treated with novel antifungal agents
Purpose: Evaluate the transcriptional profile of Neurospora crassa cells treated with a group of novel antifungal compounds Methods: Conidial suspensions were obtained and 1 x 106 cells/ml incubated in minimal medium for 6 hours (26ºC, 140 rpm, constant light) followed by the addition of the indica...
ORGANISM(S): Neurospora crassa 
2015-11-25 | E-GEOD-53040 | biostudies-arrayexpress
TranscriptomicsIn depth characterization of the activity of a novel synthetic macrocyclic antifungal compound
The systemic infections by peptogenous fungi member of the genera Candida and Aspergillus represent a serious threat for public health. During previous research we have successfully identified a family of compounds active against different Candida spp. including strains resistant to antifungal drugs...
ORGANISM(S): Candida albicans 
2015-04-01 | E-GEOD-65396 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics as a hypothesis-generation tool in plant protection product discovery: Highlighting the potential of trehalose and glycerol metabolism of fungal conidiospores as novel targets

INTRODUCTION: The production of high quality and safe food represents a main priority for the agri-food sector in the effort to sustain the exponentially growing human population. Nonetheless, there are major challenges that require the discovery of new, alternative, and improved...

2020-09-08 | MTBLS1565 | MetaboLights
TranscriptomicsEvolutionary divergence in the fungal response to fluconazole revealed by soft clustering (S. cerevisiae, C. glabrata, K. lactis)
Fungal infections are an emerging health risk, especially those involving yeast that are resistant to antifungal agents. To understand the range of mechanisms by which yeasts can respond to anti-fungals, we compared gene expression patterns across three evolutionarily distant species - Saccharomyces...
ORGANISM(S): Candida glabrata 
2010-07-08 | E-GEOD-15710 | biostudies-arrayexpress
GenomicsAntifungal activity of the repurposed drug disulfiram against Cryptococcus neoformans.
Antifungal activity of the repurposed drug disulfiram against Cryptococcus neoformans.
PRJNA1046536 | ENA
ProteomicsSuppressed Protein Translation Caused by MSP-8 Defect Determines Fungal Multidrug Resistance with Fitness Cost
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
ORGANISM(S): Neurospora Crassa Or74a 
PXD054574 |
TranscriptomicsIdentification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans
The identification of novel transcription factors associated to antifungal response may allow the discovery of fungal specific targets for new therapeutic strategies. A collection of 241 C. albicans transcriptional regulators mutants was screened for altered susceptibility to fluconazole, caspofungi...
ORGANISM(S): Candida albicans 
2012-05-02 | E-GEOD-37682 | biostudies-arrayexpress
TranscriptomicsResponse of Candida albicans towards a novel antifungal benzimidazole derivative
Fungal infections are a serious health problem in the clinic especially in the immunocompromised patient. Disease ranges from widespread superficial vulvovaginal infections to life-threatening systemic candidiasis. Especially for systemic mycoses only a limited arsenal of antimycotica are available,...
ORGANISM(S): Candida albicans 
2011-07-14 | E-GEOD-21622 | biostudies-arrayexpress
GenomicsBarcode sequencing of Saccharomyces cerevisiae deletion libraries, SYBARIS project
A systematic approach allowing the identification of the molecular way-of-action of novel potential drugs represents the golden-tool for drug-discovery. While high-throughput screening technologies of large libraries is now well established, the assessment of the drug targets and mechanism of action...
ORGANISM(S): Saccharomyces cerevisiae 
2016-04-30 | E-SYBR-6 | biostudies-arrayexpress
UnknownThe Future of Antifungal Drug Therapy: Novel Compounds and Targets.
Not available
S-EPMC7848987 | biostudies-literature
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