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TranscriptomicsTranscription profiling of human muscle specimens from 10 HIBM patients carrying the M712T Persian Jewish founder mutation to investigate hereditary inclusion body myopathy (HIBM)
HIBM is a neuromuscular disorder characterized by adult-onset, slowly progressive distal and proximal muscle weakness. Here, gene expression was measured in muscle specimens from 10 HIBM patients carrying the M712T Persian Jewish founder mutation in GNE and presenting with mild histological changes,...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12648 | biostudies-arrayexpress
TranscriptomicsDensely interconnected transcriptional circuits control cell states in human hematopoiesis
Tremendous progress has been made in identifying individual transcription factors that regulate hematopoietic differentiation, but many aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cel...
ORGANISM(S): Homo sapiens 
2011-01-21 | E-GEOD-24759 | biostudies-arrayexpress
GenomicsDerivation of novel human ground state naM-CM-/ve pluripotent stem cells.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-52824 | biostudies-arrayexpress
GenomicsDerivation of novel human ground state naM-CM-/ve pluripotent stem cells
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2 and GSK3b signalling ...
ORGANISM(S): Homo sapiens 
2013-11-28 | E-GEOD-52617 | biostudies-arrayexpress
GenomicsThe H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [ChIP-Seq]
Pluripotency can be induced in somatic cells by ectopic expression of defined transcription factors, however the identity of epigenetic regulators driving the progression of cellular reprogramming requires further investigation. Here we uncover a non-redundant role for the JmjC-domain-containing pro...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-37821 | biostudies-arrayexpress
GenomicsThe H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency
This SuperSeries is composed of the following subset Series: GSE35775: The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [Affymetrix gene expression] GSE37821: The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to p...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-37822 | biostudies-arrayexpress
Transcriptomicsm6A RNA Methylation is Critical for Adequate Exit from NaM-CM-/ve Pluripotency and Execution of Mammalian Development
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-02 | E-GEOD-61998 | biostudies-arrayexpress
GenomicsFrequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-Differentiation with iPSCs Reprogramming Factors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-04-30 | E-GEOD-67299 | biostudies-arrayexpress
TranscriptomicsThe H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [Affymetrix gene expression]
Pluripotency can be induced in somatic cells by ectopic expression of defined transcription factors, however the identity of epigenetic regulators driving the progression of cellular reprogramming requires further investigation. Here we uncover a non-redundant role for the JmjC-domain-containing pro...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-35775 | biostudies-arrayexpress
TranscriptomicsDerivation of novel human ground state naM-CM-/ve pluripotent stem cells
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2 and GSK3b signalling ...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-46872 | biostudies-arrayexpress
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